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Reduction of immune function in life stress and depression

Irwin, Michael, Patterson, Tom, Smith, Tom L., Caldwell, Cindy, Brown, Sandra A., Gillin, J.Christian, Grant, Igor·1990·Biological Psychiatry
DOI 10.1016/0006-3223(90)90016-u
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Abstract

Reduced cell-mediated immune function has been found in depressed patients and in distressed persons undergoing threatening life events. The present study examines the interaction between severe life stress and major depression to produce immune alterations in 36 matched pairs of hospitalized depressed patients and nondepressed controls. Both major depressive disorder and the presence of threatening life events in control subjects are independently associated with a 50% reduction of natural killer (NK) cytotoxicity. A decrease in natural cytotoxicity is significantly associated with depressive symptoms but not with age, alcohol consumption, or tobacco smoking. These findings of altered immunity provide further evidence that the physiological responses in chronic stress parallel those found in the syndrome of depression.

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Research works printed but not linked: 24

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Metadata

Authors
Irwin, M., Patterson, T., Smith, T. L., Caldwell, C., Brown, S. A., Gillin, J. C., & Grant, I.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1990-01
Volume
27
Issue
1
Pages
22-30
ISSN
0006-3223
DOI
10.1016/0006-3223(90)90016-u
Cited by
253
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Reduction of immune function in life stress and depression. https://app.cochat.ai/papers/10.1016/0006-3223(90)90016-u
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Irwin, M., Patterson, T., Smith, T. L., Caldwell, C., Brown, S. A., Gillin, J. C., & Grant, I. (1990). Reduction of immune function in life stress and depression. Biological Psychiatry. https://doi.org/10.1016/0006-3223(90)90016-u