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Cited by 676Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Depressive disorders and immunity: 20 years of progress and discovery

Irwin, Michael R., Miller, Andrew H.·2007·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2007.01.010
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Abstract

Since the inception of Brain, Behavior and Immunity twenty years ago, many exciting developments have occurred regarding the relationship between depression and the immune system. These developments have increasingly put the field of psychoneuroimmunology into a clinical context with important translational implications. Initial studies focused on the impact of depression on relatively narrowly defined immunologic endpoints, which ultimately found their relevance in studies examining the effect of depression on immunologically-based diseases including infectious illnesses, autoimmune disorders, and cancer as well as more recently cardiovascular disease. Mechanistic studies have also greatly contributed to an understanding of those facets of depression, which might mediate these effects. More recently, the reciprocal influences of the immune system on the brain and behavior including depression have taken center stage. Increasing data now indicate that activated inflammatory processes can influence multiple aspects of CNS function including neurotransmitter metabolism, neuroendocrine function, and information processing leading to behavioral changes in humans that bespeak depression. These latter developments have intrigued scientists investigating the pathophysiology of depression and warrant consideration as some of the most exciting new developments in psychiatry in the past 20 years. What the future holds is a world of promise as multiple translational targets derived from the cytokine model of depression work their way into the clinical arena as drug targets for further development. Moreover, the work has served to instantiate brain-immune interactions as an essential component in psychiatric and medical co-morbidities and their impact on health and illness.

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Crossref · 10.1016/j.bbi.2007.01.010

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74 of 74 references verified0 citation errors · 0 not checkable

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  • Depression is accompanied by cell-mediated immune activation, which involves macrophages, monocytes, and T-lymphocytes.

    “depression is accompanied not just by increases in circulating markers of inflammation but also by cell-mediated immune activation, which involves macrophages, monocytes, and T-lymphocytes”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Irwin & Miller, 2007

  • Importance of religious or spiritual expression was related to significantly higher white blood cell count, total lymphocyte count, total T cells, and cytotoxic T cell activity.

    “importance of religious or spiritual expression was related to significantly higher white blood cell count, total lymphocyte count, total T cells, and cytotoxic T cell activity.”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [448]

  • In the same immune function study, religious attendance was also related at a trend level to higher total lymphocyte count, total T-cell count, and helper T-cell count.

    “it was also related (at a trend level) to higher total lymphocyte count, total T-cell count, and helper T-cell count.”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [448]

  • In one immune function study, religious attendance was related to significantly poorer cutaneous response to antigens.

    “In that study, religious attendance was related to significantly poorer cutaneous response to antigens”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [448]

  • No high-quality immune function study found only an inverse association or negative effect, although one study reported mixed findings.

    “No high-quality study found only an inverse association or negative effect, although one study reported mixed findings [448].”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [448]

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Authors
Irwin, M. R., & Miller, A. H.
Affiliations
  • University of California, Los Angeles (US)
  • Emory University (US)
Corresponding author
Irwin, Michael R.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2007-05
Volume
21
Issue
4
Pages
374-383
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2007.01.010
OpenAlex
W1964368905
Cited by
676
References
74
Citations by year
2026: 15 · 2025: 25 · 2024: 39 · 2023: 18 · 2022: 28 · 2021: 38 · 2020: 29 · 2019: 38 · 2018: 39 · 2017: 33 · 2016: 25 · 2015: 41 · 2014: 46 · 2013: 39 · 2012: 53
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG 026364, R01AG026364)
  • National Heart, Lung, and Blood Institute (HL 079955, R01HL079955)
  • National Institute of Mental Health (MH-55253, R01MH055253, MH 19925, T32MH019925)
  • National Cancer Institute (CA-10014152)
  • National Center for Research Resources (M01RR000827)
  • NIH Clinical Center
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, psychoneuroimmunology, immune system, cytokines, inflammation, neuroimmune interactions, autoimmune disease, infectious diseases, cancer, cardiovascular disease, neurotransmitter metabolism, neuroendocrine function, psychiatric comorbidity, translational research, therapeutic target
MeSH terms
Depressive Disorder, Forecasting, Humans, Psychoneuroimmunology, Neuroimmunomodulation, Cytokines, History, 20th Century, History, 21st Century

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