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Cited by 125Schizophrenia research and treatmentCoffee research and impactsNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.

Effects of the acute administration of caffeine in patients with schizophrenia

Lucas, Peter B., Pickar, David, Kelsoe, John, Rapaport, Mark, Pato, Carlos, Hommer, Daniel·1990·Biological Psychiatry
DOI 10.1016/0006-3223(90)90429-6
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Abstract

Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled study of its behavioral effects. Some measures of psychopathology were significantly increased: Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content, and euphoria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of psychosis and mania, comparing the day before with the day after pharmacological challenge, increased significantly. Compared to placebo, caffeine also produced significant increases of diastolic blood pressure and cortisol. Thus, these findings indicate that caffeine increases arousal and has a psychotogenic effect when administered to schizophrenic patients. The possible roles of various neurotransmitters is discussed with special emphasis on caffeine's actions on dopaminergic and adenosinergic systems.

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Crossref · 10.1016/0006-3223(90)90429-6

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27 of 27 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Lucas, P. B., Pickar, D., Kelsoe, J., Rapaport, M., Pato, C., & Hommer, D.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Pickar, David
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1990-07
Volume
28
Issue
1
Pages
35-40
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(90)90429-6
OpenAlex
W1979225061
Cited by
125
References
29
Citations by year
2026: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
3.42
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
caffeine, schizophrenia, psychopathology, arousal, psychosis, mania, blood pressure, cortisol, dopaminergic system, adenosinergic system, neurotransmitters
MeSH terms
Adolescent, Adult, Arousal, Caffeine, Female, Humans, Hydrocortisone, Male, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology

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