Cited by 125Schizophrenia research and treatmentCoffee research and impactsNeurotransmitter Receptor Influence on Behavior

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Effects of the acute administration of caffeine in patients with schizophrenia

Lucas, Peter B., Pickar, David, Kelsoe, John, Rapaport, Mark, Pato, Carlos, Hommer, Daniel·1990·Biological Psychiatry

DOI 10.1016/0006-3223(90)90429-6

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Abstract

Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled study of its behavioral effects. Some measures of psychopathology were significantly increased: Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content, and euphoria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of psychosis and mania, comparing the day before with the day after pharmacological challenge, increased significantly. Compared to placebo, caffeine also produced significant increases of diastolic blood pressure and cortisol. Thus, these findings indicate that caffeine increases arousal and has a psychotogenic effect when administered to schizophrenic patients. The possible roles of various neurotransmitters is discussed with special emphasis on caffeine's actions on dopaminergic and adenosinergic systems.

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Authors: Lucas, P. B., Pickar, D., Kelsoe, J., Rapaport, M., Pato, C., & Hommer, D.
Affiliations: National Institute of Mental Health (US)
Corresponding author: Pickar, David
ORCID: Kelsoe, John
Rapaport, Mark
Pato, Carlos
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1990-07
Volume: 28
Issue: 1
Pages: 35-40
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(90)90429-6
OpenAlex: W1979225061
Cited by: 125
References: 29
Citations by year: 2026: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 3.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: caffeine, schizophrenia, psychopathology, arousal, psychosis, mania, blood pressure, cortisol, dopaminergic system, adenosinergic system, neurotransmitters
MeSH terms: Adolescent, Adult, Arousal, Caffeine, Female, Humans, Hydrocortisone, Male, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology

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Effects of the acute administration of caffeine in patients with schizophrenia

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