The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.
Effects of the acute administration of caffeine in patients with schizophrenia
Abstract
Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled study of its behavioral effects. Some measures of psychopathology were significantly increased: Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content, and euphoria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of psychosis and mania, comparing the day before with the day after pharmacological challenge, increased significantly. Compared to placebo, caffeine also produced significant increases of diastolic blood pressure and cortisol. Thus, these findings indicate that caffeine increases arousal and has a psychotogenic effect when administered to schizophrenic patients. The possible roles of various neurotransmitters is discussed with special emphasis on caffeine's actions on dopaminergic and adenosinergic systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For other mental illness, such as schizophrenia, caffeine may exacerbate psychotic symptoms (209), although the majority of this literature is informed by case studies, with very few double-blind placebo-controlled studies (210).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [209]
Citations
Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Molecular pathology of schizophrenia: more than one disease process?
Crow, T. J. (1980) · BMJ · doi:10.1136/bmj.280.6207.66 · Cited by 1,862
The Two-syndrome Concept: Origins and Current Status
Crow, T. J. (1985) · Schizophrenia Bulletin · doi:10.1093/schbul/11.3.471 · Cited by 841
Bruns, R. F., Daly, J. W., & Snyder, S. H. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5547 · Cited by 549
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501
Methods for Reliable Longitudinal Observation of Behavior
Bunney, W. E. (1963) · Archives of General Psychiatry · doi:10.1001/archpsyc.1963.01720150090010 · Cited by 480
Increased Anxiogenic Effects of Caffeine in Panic Disorders
Charney, D. S. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790260027003 · Cited by 428
Provocation of Schizophrenic Symptoms by Intravenous Administration of Methylphenidate
Janowsky, D. S. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750320023004 · Cited by 310
Methylphenidate, Dextroamphetamine, and Levamfetamine
Janowsky, D. S. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770030024003 · Cited by 205
Increased Sensitivity to Caffeine in Patients With Panic Disorders
Boulenger, J. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790220057009 · Cited by 193
Radioimmunoassay of Plasma Cortisol
Abraham, G. E., Buster, J. E., & Teller, R. C. (1972) · Analytical Letters · doi:10.1080/00032717208069558 · Cited by 140
Snyder, S. H., & Sklar, P. B. (1984) · Journal of Psychiatric Research · doi:10.1016/0022-3956(84)90001-3 · Cited by 124
Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain
Waldeck, B. (1971) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1971.tb10198.x · Cited by 102
CNS stimulants as tools in the study of schizophrenia
Angrist, B., & van Kammen, D. P. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80062-4 · Cited by 100
Mikkelsen, E. J. (1978) · PubMed · Cited by 97
Caffeine: relationship to human anxiety, plasma MHPG and cortisol.
Uhde, T. W., Boulenger, J.-P., Jimerson, D. C., & Post, R. M. (1984) · PubMed · Cited by 96
Effects of caffeine in chronic psychiatric patients
Freitas, B. D., & Schwartz, G. J. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.10.1337 · Cited by 96
Charney, D. S., Galloway, M. P., & Heninger, G. R. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90132-2 · Cited by 95
Ammon, H., Bieck, P., Mandalaz, D., & Verspohl, E. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb01553.x · Cited by 86
Andén, N., & Jackson, D. M. (1975) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1975.tb09529.x · Cited by 55
MANAMY, M. C. M., & Schube, P. G. (1936) · New England Journal of Medicine · doi:10.1056/nejm193610012151403 · Cited by 47
Caffeine toxicity as a cause of acute psychosis in anorexia nervosa
Shaul, P. W., Farrell, M. K., & Maloney, M. J. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80037-2 · Cited by 33
Preferential effects of caffeine on limbic and cortical dopamine systems
Stoner, G. R., Skirboll, L. R., Werkman, S., & Hommer, D. W. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90064-9 · Cited by 31
Self-citationCaffeine actions and adenosine.
Gould, R. J., MURPHY, K. M. M., Katims, J. J., & Snyder, S. H. (1984) · PubMed · Cited by 26
The Two-Syndrome Concept and Neuroendocrinology of Schizophrenia
Crow, T. J., Ferner, I. N., & Johnstone, E. C. (1986) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30637-3 · Cited by 23
Diet aids, mania, and affective illness
Achor, M., & Extein, I. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.3.392a · Cited by 20
Effects of methylphenidate in adult psychiatric inpatients: a preliminary report.
Huey, L. Y., Ds, J., Judd, L. L., WHITEHALL, W., Zetin, M., Sc, R., & Loevinger, B. L. (1984) · PubMed · Cited by 7
Cited by
Sorted by citations
Nehlig, A., Daval, J., & Debry, G. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90012-b · Cited by 1,463
Schizophrenia: A neural diathesis-stress model.
Walker, E. F., & Diforio, D. (1997) · Psychological Review · doi:10.1037//0033-295x.104.4.667 · Cited by 930
Cigarette smoking in schizophrenia: relationship to psychopathology and medication side effects
GOFF, D. C., Henderson, D. C., & Amico, E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1189 · Cited by 576
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Purinergic signalling: From normal behaviour to pathological brain function
Burnstock, G., Krügel, U., Abbracchio, M. P., & Illés, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.006 · Cited by 402
Metadata
- Authors
- Lucas, P. B., Pickar, D., Kelsoe, J., Rapaport, M., Pato, C., & Hommer, D.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Pickar, David
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 28
- Issue
- 1
- Pages
- 35-40
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1979225061
- Cited by
- 125
- References
- 29
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- caffeine, schizophrenia, psychopathology, arousal, psychosis, mania, blood pressure, cortisol, dopaminergic system, adenosinergic system, neurotransmitters
- MeSH terms
- Adolescent, Adult, Arousal, Caffeine, Female, Humans, Hydrocortisone, Male, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
