Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double‐blind crossover study.
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In a double‐blind crossover trial, the effect of 4 week daily ingestion of eight cups of regular coffee (corresponding to 504 mg caffeine) vs eight cups of decaffeinated coffee was studied. Blood pressure, heart rate and urinary catecholamines were measured in eight healthy, young volunteers. In both groups, regular coffee immediately led to a significant increase in mean blood pressure (+ 3 and + 5 mm Hg respectively). The difference between both groups, however, existed only in the first 3 to 5 days of ingestion of regular coffee. On day 5 after ingestion of regular coffee, and thereafter in weekly intervals, no significant increase in catecholamine excretion was observed. The data suggest that long‐term consumption of large amounts of coffee leads to only a small and transient rise in mean blood pressure. This may be due to an adaptation phenomenon. Therefore, continuous heavy coffee ingestion (eight cups/day for 4 weeks) by young persons does not appear to involve a risk of the development of hypertension.
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Some studies have shown that habitual consumption results in tolerance to the acute effects of caffeine, while others have found that some individuals continue to experience these acute effects with each drinking episode and that tolerance disappears after 12 hours of abstinence.
“Some studies have shown that habitual consumption results in a tolerance to the acute effects of caffeine, 18,19 while others have found that some individuals continue to experience these acute effects with each drinking episode 20,21 and that the tolerance disappears after 12 hours of abstinence.22”
From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [19]
These results are concordant with our finding of no increased risk among those who drink coffee regularly, suggesting that habitual consumption results in a tolerance to the acute effects of caffeine.
“These results are concordant with our finding of no increased risk among those who drink coffee regularly, suggesting that habitual consumption results in a tolerance to the acute effects of caffeine.18,19”
From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [19]
Earlier studies claiming tolerance to pressor effects of caffeine did not mirror normal staggered caffeine consumption.
“Earlier studies which claimed to show tolerance to the pressor effects of caffeine [11,[16][17][18] have not mirrored 'normal' staggered caffeine consumption but are characterized by a prior period of prolonged abstinence followed by a high dose of caffeine administered once or twice daily.”
From Central and peripheral effects of sustained caffeine use: tolerance is incomplete (2002) · cites this paper as [16]
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- Authors
- Ammon, H., Bieck, P., Mandalaz, D., & Verspohl, E.
- Affiliations
- University of Tübingen (DE)
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1983-06
- Volume
- 15
- Issue
- 6
- Pages
- 701-706
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1427936
- OpenAlex
- W1993785831
- Cited by
- 86
- References
- 18
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- coffee consumption, caffeine, blood pressure, hypertension risk, urinary catecholamines, heart rate, decaffeinated coffee, young adults
- MeSH terms
- Adaptation, Physiological, Adult, Blood Pressure, Catecholamines, Coffee, Double-Blind Method, Heart Rate, Humans, Male, Time Factors
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