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Cited by 154Circadian rhythm and melatoninSchizophrenia research and treatmentMental Health and Psychiatry

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia

Rao, Maria Luise, Gross, Gisela, Strebel, Bernd, Halaris, Angelos, Huber, Gerd, Bräunig, Peter, Marler, Matthew·1994·Biological Psychiatry
DOI 10.1016/0006-3223(94)91147-9
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Abstract

Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schizophrenia or their influence on neuroleptic drugs. We showed previously that the MESOR of dopamine is higher in schizophrenic patients than in healthy subjects and that women who are drug-free schizophrenic have lower prolactin MESORs and lower amplitudes than healthy women. We now report the data of a cosinor analysis of tryptophan, serotonin, melatonin, and pituitary hormones in the blood of 34 healthy subjects, 90 drug-free schizophrenics, and 25 neuroleptic-treated schizophrenic patients. This data indicated a significant phase advance of serum tryptophan, prolactin, and melatonin concentrations, a trend toward a phase advance in serotonin. Thyroid stimulating hormone (TSH), and growth hormone concentrations, and decreases in the TSH MESORs among patients compared to healthy subjects. These results suggest that circadian changes, such as phase advances and alterations in MESOR, are not only present in depression but also in schizophrenia. Although neuroleptic treatment raised the prolactin MESOR and amplitude, it did not elicit any change in circadian rhythmicity among the other parameters.

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Crossref · 10.1016/0006-3223(94)91147-9

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Research works printed but not linked: 2

  1. Fernstrom, 1988, Tryptophan availability and serotinin synthesis in brain, vol. 20, 201
  2. Kishimoto, 1977, The biochemical studies of manic-depressive psychosis: I. The circadian rhythm of plasma trypophan, tyrosine and cortisol, and its clinical significance, Yokohama Med Bull, 28, 23

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Metadata

Authors
Rao, M. L., Gross, G., Strebel, B., Halaris, A., Huber, G., Bräunig, P., & Marler, M.
Affiliations
  • University of Bonn (DE)
  • University of Mississippi (US)
Corresponding author
Rao, Maria Luise
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1994-02
Volume
35
Issue
3
Pages
151-163
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(94)91147-9
OpenAlex
W2172147562
Cited by
154
References
78
Citations by year
2026: 3 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 8
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
circadian rhythm, schizophrenia, tryptophan, serotonin, melatonin, prolactin, pituitary hormones, thyroid-stimulating hormone, growth hormone, antipsychotic drugs, mesor, phase advance, cosinor analysis
MeSH terms
Adolescent, Adult, Aged, Circadian Rhythm, Female, Humans, Hypothalamo-Hypophyseal System, Male, Melatonin, Middle Aged, Neural Inhibition, Pituitary Hormones, Prolactin, Reference Values, Schizophrenia, Schizophrenic Psychology, Serotonin, Growth Hormone, Thyrotropin, Antipsychotic Agents, Tryptophan

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