Cited by 154Circadian rhythm and melatoninSchizophrenia research and treatmentMental Health and Psychiatry

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Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia

Rao, Maria Luise, Gross, Gisela, Strebel, Bernd, Halaris, Angelos, Huber, Gerd, Bräunig, Peter, Marler, Matthew·1994·Biological Psychiatry

DOI 10.1016/0006-3223(94)91147-9

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Abstract

Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schizophrenia or their influence on neuroleptic drugs. We showed previously that the MESOR of dopamine is higher in schizophrenic patients than in healthy subjects and that women who are drug-free schizophrenic have lower prolactin MESORs and lower amplitudes than healthy women. We now report the data of a cosinor analysis of tryptophan, serotonin, melatonin, and pituitary hormones in the blood of 34 healthy subjects, 90 drug-free schizophrenics, and 25 neuroleptic-treated schizophrenic patients. This data indicated a significant phase advance of serum tryptophan, prolactin, and melatonin concentrations, a trend toward a phase advance in serotonin. Thyroid stimulating hormone (TSH), and growth hormone concentrations, and decreases in the TSH MESORs among patients compared to healthy subjects. These results suggest that circadian changes, such as phase advances and alterations in MESOR, are not only present in depression but also in schizophrenia. Although neuroleptic treatment raised the prolactin MESOR and amplitude, it did not elicit any change in circadian rhythmicity among the other parameters.

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Authors: Rao, M. L., Gross, G., Strebel, B., Halaris, A., Huber, G., Bräunig, P., & Marler, M.
Affiliations: University of Bonn (DE)
University of Mississippi (US)
Corresponding author: Rao, Maria Luise
ORCID: Halaris, Angelos
Huber, Gerd
Bräunig, Peter
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1994-02
Volume: 35
Issue: 3
Pages: 151-163
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(94)91147-9
OpenAlex: W2172147562
Cited by: 154
References: 78
Citations by year: 2026: 3 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 8
FWCI: 1.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: circadian rhythm, schizophrenia, tryptophan, serotonin, melatonin, prolactin, pituitary hormones, thyroid-stimulating hormone, growth hormone, antipsychotic drugs, mesor, phase advance, cosinor analysis
MeSH terms: Adolescent, Adult, Aged, Circadian Rhythm, Female, Humans, Hypothalamo-Hypophyseal System, Male, Melatonin, Middle Aged, Neural Inhibition, Pituitary Hormones, Prolactin, Reference Values, Schizophrenia, Schizophrenic Psychology, Serotonin, Growth Hormone, Thyrotropin, Antipsychotic Agents, Tryptophan

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Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia

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