Cited by 396Circadian rhythm and melatoninStress Responses and CortisolTreatment of Major Depression

Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality

Souêtre, Eric, Salvati, Edouard, Belugou, Jean-Luc, Pringuey, Dominique, Candito, Mirande, Krebs, Bernard, Ardisson, Jean-Louis, Darcourt, Guy·1989·Psychiatry Research

Abstract

Circadian rhythms of body temperature, plasma cortisol, norepinephrine (NE), thyroid stimulating hormone (TSH), and melatonin were compared in 16 endogenously depressed, 15 recovered (after 3 weeks of anti-depressant treatment), and 16 normal subjects. The depressed patients showed clear circadian rhythm abnormalities, consisting mainly in amplitude reduction. This amplitude reduction was significantly correlated with the patients' Hamilton depression scores. Normal circadian profiles were restored after recovery when amplitude, in particular, was increased. Features of the circadian rhythms observed in remission may be associated with antidepressant drug effects, whereas those observed in depression resemble the circadian rhythms observed in normal subjects living under conditions of temporal isolation and those of blind subjects. Our findings suggest that depression may be related both to a weakening of the coupling processes between internal pacemakers and to an abnormal sensitivity to environmental information.

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Crossref · 10.1016/0165-1781(89)90207-2

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  • Blunted or abnormal circadian rhythms in body temperature, plasma cortisol, norepinephrine, thyroid stimulating hormone, blood pressure, pulse, and melatonin have been found in depressed and bipolar patients.

    “Indeed, blunted or abnormal circadian rhythms in a variety of bodily functions including body temperature, plasma cortisol, norepinephrine, thyroid stimulating hormone, blood pressure, pulse, and melatonin have been found in depressed and bipolar patients (Atkinson et al., 1975; Kripke et al., 1978; Souetre et al., 1989).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Souetre et al., 1989

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Authors
Souêtre, E., Salvati, E., Belugou, J.-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J.-L., & Darcourt, G.
Affiliations
Hôpital Pasteur (FR)
Corresponding author
Souêtre, Eric
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1989-06
Volume
28
Issue
3
Pages
263-278
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2058331036
Cited by
396
References
59
Citations by year
2026: 7 · 2025: 5 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 18 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 20
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
circadian rhythm, depression, remission, antidepressant treatment, body temperature, cortisol, norepinephrine, thyroid-stimulating hormone, melatonin, chronobiology, temporal isolation, blind subjects
MeSH terms
Adult, Amitriptyline, Body Temperature Regulation, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Imipramine, Lithium, Male, Melatonin, Middle Aged, Norepinephrine, Psychiatric Status Rating Scales, Sleep Stages, Thyrotropin, Wakefulness

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