Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality
Abstract
Circadian rhythms of body temperature, plasma cortisol, norepinephrine (NE), thyroid stimulating hormone (TSH), and melatonin were compared in 16 endogenously depressed, 15 recovered (after 3 weeks of anti-depressant treatment), and 16 normal subjects. The depressed patients showed clear circadian rhythm abnormalities, consisting mainly in amplitude reduction. This amplitude reduction was significantly correlated with the patients' Hamilton depression scores. Normal circadian profiles were restored after recovery when amplitude, in particular, was increased. Features of the circadian rhythms observed in remission may be associated with antidepressant drug effects, whereas those observed in depression resemble the circadian rhythms observed in normal subjects living under conditions of temporal isolation and those of blind subjects. Our findings suggest that depression may be related both to a weakening of the coupling processes between internal pacemakers and to an abnormal sensitivity to environmental information.
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Blunted or abnormal circadian rhythms in body temperature, plasma cortisol, norepinephrine, thyroid stimulating hormone, blood pressure, pulse, and melatonin have been found in depressed and bipolar patients.
“Indeed, blunted or abnormal circadian rhythms in a variety of bodily functions including body temperature, plasma cortisol, norepinephrine, thyroid stimulating hormone, blood pressure, pulse, and melatonin have been found in depressed and bipolar patients (Atkinson et al., 1975; Kripke et al., 1978; Souetre et al., 1989).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Souetre et al., 1989
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- Authors
- Souêtre, E., Salvati, E., Belugou, J.-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J.-L., & Darcourt, G.
- Affiliations
- Hôpital Pasteur (FR)
- Corresponding author
- Souêtre, Eric
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1989-06
- Volume
- 28
- Issue
- 3
- Pages
- 263-278
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2058331036
- Cited by
- 396
- References
- 59
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 18 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 20
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- circadian rhythm, depression, remission, antidepressant treatment, body temperature, cortisol, norepinephrine, thyroid-stimulating hormone, melatonin, chronobiology, temporal isolation, blind subjects
- MeSH terms
- Adult, Amitriptyline, Body Temperature Regulation, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Imipramine, Lithium, Male, Melatonin, Middle Aged, Norepinephrine, Psychiatric Status Rating Scales, Sleep Stages, Thyrotropin, Wakefulness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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