The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Substance P containing and cholinergic projections from the habenula
Abstract
Electrolytic lesions and surgical transection of the habenulo-interpeduncular-ventrotegmental tract have established the existence of separate habenulo-interpeduncular-ventrotegmental substance P and cholinergic projections. Micro-knife lesions separating the habenula nuclei showed the medial habenular nucleus to be the source of substance P fibres running via the fasciculus retroflexus to the ventral tegmental area. The lateral habenular nucleus receives a substance P projection from the medial habenular nucleus and is the source of cholinergic projection to the interpeduncular nucleus and to the medial habenular nucleus. Lesions of the ventrotegmental-interpeduncular area did not modify the levels of substance P and choline acetyltransferase in the habenula. These observations suggested that there are no substance P or ACh containing afferents to the habenula from the ventrotegmental-interpeduncular area and the accumulation of substance P and AChE proximal to but not caudal to transections of the fasciculus retroflexus confirmed this view.
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“MHb is comprised of neurons that produce the neurotransmitters acetylcholine (ACh) or substance P (Cuello et al. 1978;Eckenrode et al. 1987), and a small population that produce the cytokine interleukin-18 (IL-18) (Sugama et al. 2002).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Cuello et al. 1978
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Metadata
- Authors
- Claudio Cuello, A., Emson, P. C., Paxinos, G., & Jessell, T.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Paxinos, George
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1978-06
- Volume
- 149
- Issue
- 2
- Pages
- 413-429
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2020107272
- Cited by
- 197
- References
- 41
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- substance P, cholinergic projections, habenula, fasciculus retroflexus, ventral tegmental area, interpeduncular nucleus, choline acetyltransferase, afferent projections
- MeSH terms
- Acetylcholinesterase, Animals, Cholinergic Fibers, Fluorescent Antibody Technique, Male, Neural Pathways, Substance P, Tegmentum Mesencephali, Thalamic Nuclei, Rats
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