Cited by 197Neuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Substance P containing and cholinergic projections from the habenula

Claudio Cuello, A., Emson, Piers C., Paxinos, George, Jessell, Thomas·1978·Brain Research

DOI 10.1016/0006-8993(78)90484-5

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Abstract

Electrolytic lesions and surgical transection of the habenulo-interpeduncular-ventrotegmental tract have established the existence of separate habenulo-interpeduncular-ventrotegmental substance P and cholinergic projections. Micro-knife lesions separating the habenula nuclei showed the medial habenular nucleus to be the source of substance P fibres running via the fasciculus retroflexus to the ventral tegmental area. The lateral habenular nucleus receives a substance P projection from the medial habenular nucleus and is the source of cholinergic projection to the interpeduncular nucleus and to the medial habenular nucleus. Lesions of the ventrotegmental-interpeduncular area did not modify the levels of substance P and choline acetyltransferase in the habenula. These observations suggested that there are no substance P or ACh containing afferents to the habenula from the ventrotegmental-interpeduncular area and the accumulation of substance P and AChE proximal to but not caudal to transections of the fasciculus retroflexus confirmed this view.

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Authors: Claudio Cuello, A., Emson, P. C., Paxinos, G., & Jessell, T.
Affiliations: University of Cambridge (GB)
ORCID: Paxinos, George
Venue: Brain Research
Publisher: Elsevier BV
Published: 1978-06
Volume: 149
Issue: 2
Pages: 413-429
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(78)90484-5
OpenAlex: W2020107272
Cited by: 197
References: 41
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 3
FWCI: 4.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: substance P, cholinergic projections, habenula, fasciculus retroflexus, ventral tegmental area, interpeduncular nucleus, choline acetyltransferase, afferent projections
MeSH terms: Acetylcholinesterase, Animals, Cholinergic Fibers, Fluorescent Antibody Technique, Male, Neural Pathways, Substance P, Tegmentum Mesencephali, Thalamic Nuclei, Rats

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Substance P containing and cholinergic projections from the habenula

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