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Vasopressin and oxytocin release in the brain – a synaptic event
Open accessAbstract
In order to obtain evidence for a central release of vasopressin and oxytocin, the release of these peptides was demonstrated in various extrahypothalamic areas of the rat brain. It proved that in those areas where these peptidergic fibers terminate synaptically a vasopressin and/or oxytocin calcium-dependent release, similar to that in the neurohypophysis, could be evoked by potassium or veratridine. Such release was not found in areas in which these fibers do not exhibit synaptic specialization.
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“Non-synaptic neuropeptide release is stimulated by Ca2+ coming from intracellular stores (e.g., endoplasmic reticulum) as opposed to synaptic release that is mediated by the influx of extracellular Ca2+ through voltage-gated channels [105].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [105]
In the citing paper
“In addition, depolarizing stimuli can induce OT and AVP release in a calcium-dependent manner in brain regions where AVP and OT fibers terminate synaptically [105; 106; 107].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [105]
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Metadata
- Authors
- Buijs, R. M., & Heerikhuize, J. J. V.
- ORCID
- Buijs, R.M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 252
- Issue
- 1
- Pages
- 71-76
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2092863206
- Cited by
- 218
- References
- 23
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2013: 1
- FWCI
- 25.58
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- vasopressin, oxytocin, synaptic release, calcium-dependent exocytosis, potassium-evoked release, veratridine, neurohypophysis
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Male, Medulla Oblongata, Nerve Fibers, Oxytocin, Paraventricular Hypothalamic Nucleus, Rats, Inbred Strains, Septum Pellucidum, Supraoptic Nucleus, Synapses, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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