Cited by 27Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Diversity of central oxytocinergic projections

Jirikowski, Gustav F.·2019·Cell and Tissue Research

Abstract

Localization and distribution of hypothalamic neurons expressing the nonapeptide oxytocin has been extensively studied. Their projections to the neurohypophyseal system release oxytocin into the systemic circulation thus controlling endocrine events associated with reproduction in males and females. Oxytocinergic neurons seem to be confined to the ventral hypothalamus in all mammals. Groups of such cells located outside the supraoptic and the paraventricular nuclei are summarized as "accessory neurons." Although evolutionary probably associated with the classical magocellular nuclei, accessory oxytocin neurons seem to consist of rather heterogenous groups: Periventricular oxytocin neurons may gain contact to the third ventricle to secrete the peptide into the cerebrospinal fluid. Perivascular neurons may be involved in control of cerebral blood flow. They may also gain access to the portal circulation of the anterior pituitary lobe. Central projections of oxytocinergic neurons extend to portions of the limbic system, to the mesencephalon and to the brain stem. Such projections have been associated with control of behaviors, central stress response as well as motor and vegetative functions. Activity of the different oxytocinergic systems seems to be malleable to functional status, strongly influenced by systemic levels of steroid hormones.

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Crossref · 10.1007/s00441-018-2960-5

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  • Oxytocin is also produced in the medial preoptic area, where it regulates maternal and sexual behavior.

    “OXT is also produced in the medial preoptic area (MPOA), where it regulates maternal and sexual behavior (44).”
  • Paraventricular oxytocin-expressing cells send fibers to the supraoptic nucleus forming the neurohypophyseal tract, and also send projections to the thalamus, cortex, amygdala, striatum, and hippocampus.

    “Oxytocin PVN OXT-expressing cells send fibers to the SON forming the neurohypophyseal tract (44), and classical retrograde tracing and modern viral tracing strategies in rats and mice have shown that the PVN OXT-expressing cells also send projections to the thalamus, cortex, amygdala, striatum, and hippocampus (Fig. 1A (53)(54)(55).”
  • Supraoptic oxytocin-expressing cells have more restricted projections, mainly to the posterior pituitary, but also project to the medial and central amygdala.

    “The SON OXT-expressing cells have more restricted projections, mainly to the posterior pituitary, but also project to the medial and central amygdala (44).”

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Authors
Jirikowski, G. F.
Affiliations
Jena University Hospital (DE)
Corresponding author
Jirikowski, Gustav F.
Venue
Cell and Tissue Research
Published
2018-11-29
Volume
375
Issue
1
Pages
41-48
ISSN
  • 0302-766X (ISSN-L)
  • 1432-0878
OpenAlex
W2902850573
Cited by
27
References
59
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2022: 8 · 2021: 6 · 2020: 3 · 2018: 1
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Locations
  • Cell and Tissue Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin, oxytocinergic neurons, hypothalamus, neurohypophyseal system, supraoptic nucleus, paraventricular nucleus, limbic system, midbrain, brainstem, steroid hormones, reproduction, cerebral blood flow, cerebrospinal fluid
MeSH terms
Animals, Humans, Neurons, Oxytocin, Pituitary Gland, Posterior

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