Cited by 137Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyElectrolyte and hormonal disorders

Central and peripheral release of vasopressin and oxytocin in the conscious rat after osmotic stimulation

Landgraf, R., Neumann, Inga, Schwarzberg, H.·1988·Brain Research

Abstract

Vasopressin (AVP) and oxytocin (OXT) were measured by radioimmunoassay in push-pull perfusates and tissue samples of various brain areas, plasma and cerebrospinal fluid (CSF) of male rats in response to osmotic stimulation. Hypertonic saline caused a significant rise in plasma AVP and OXT and different changes in peptide contents, in the septum and hippocampus at 30 and 60 min after intraperitoneal injection. Push-pull perfusion (20 microliters artificial CSF/min, 30-min periods) of the septum and dorsal hippocampus of conscious, unrestrained animals revealed a significant, stimulus-evoked release of both AVP and OXT. This release was: (1) not always reflected by corresponding changes in the regional peptide content; (2) simultaneous with the peripheral release from the posterior pituitary; and (3) probably the result of synaptic/parasynaptic events as suggested by use of agents in the artificial CSF which either inhibit or facilitate the release from intact fibre terminals.

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Crossref · 10.1016/0006-8993(88)90689-0

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Authors
Landgraf, R., Neumann, I., & Schwarzberg, H.
Affiliations
Leipzig University (DE)
Corresponding author
Landgraf, R.
Venue
Brain Research
Publisher
Elsevier BV
Published
1988-08
Volume
457
Issue
2
Pages
219-225
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1973592879
Cited by
137
References
42
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 2
FWCI
14.28
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
vasopressin, oxytocin, osmotic stimulation, hypertonic saline, septum, hippocampus, neurohypophysis, cerebrospinal fluid, plasma peptide levels, synaptic release, conscious rats
MeSH terms
Animals, Brain Chemistry, Male, Osmosis, Oxytocin, Radioimmunoassay, Rats, Inbred Strains, Vasopressins, Rats

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