Changes in frequency representation in the auditory system of mice with age-related hearing impairment
Abstract
Aging C57BL/6 mice show a progressive decline in sensitivity to sound, beginning with high frequencies. In the inferior colliculus (IC), tonotopic organization--the orderly representation of frequency from low to high along the dorsoventral dimension--shows marked changes. No neurons respond to high frequencies, most respond best to a restricted range of frequencies, and ventral neurons become responsive to low frequencies. These age-related response alterations have implications for hearing problems of aging humans.
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There is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain.
“As there is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain [46–50]”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [47]
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Syka, J. (2002) · Physiological Reviews · doi:10.1152/physrev.00002.2002 · Cited by 369 · see citing works
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- Authors
- Willott, J. F.
- Affiliations
- Northern Illinois University (US)
- Corresponding author
- Willott, James F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1984-08
- Volume
- 309
- Issue
- 1
- Pages
- 159-162
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1981815757
- Cited by
- 87
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- age-related hearing loss, tonotopic organization, inferior colliculus, spectral representation, C57BL/6 mice, auditory neurons
- MeSH terms
- Acoustic Stimulation, Aging, Animals, Auditory Pathways, Hearing Loss, High-Frequency, Inferior Colliculi, Mice, Inbred C57BL, Hearing Loss, Mice
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