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Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease
Open accessAbstract
Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morphology of medium spiny I (MSI) striatal neurons, the principal target population for both nigrostriatal and corticostriatal fibers. Our quantitative data indicate that the dendritic arbor of MSI neurons in the putamen is significantly reduced in both length and number and MSI neurons are morphologically characterized by truncated dendrites with few dendritic spines and irregular, bulbous swellings. These data provide morphological evidence for the atrophy of striatal dendrites in PD and may explain, in part, the declining efficacy of chronic L-DOPA replacement therapy in advanced PD.
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“While an important question in exercise yet to be fully addressed in PD and its animal models, studies in healthy rodents subjected to different exercise paradigms have demonstrated experience-dependent increases in dendritic spine density in a number of regions including the hippocampus and cerebellum 70, 94.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [94]
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Metadata
- Authors
- McNeill, T. H., Brown, S. A., Rafols, J. A., & Shoulson, I.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- McNeill, Thomas H.
- ORCID
- Shoulson, Ira
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1988-07
- Volume
- 455
- Issue
- 1
- Pages
- 148-152
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2069550409
- Cited by
- 246
- References
- 32
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 9
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-05445, AG03644)
- National Institute of Neurological Disorders and Stroke (NS17978)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Parkinson's disease, medium spiny neurons, dendritic atrophy, deafferentation, putamen, dendritic spines, substantia nigra, L-dopa therapy, neuronal morphology
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Corpus Striatum, Dendrites, Humans, Neurons, Parkinson Disease, Reference Values
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