Cited by 246Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeuroscience and Neuropharmacology Research

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Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease

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McNeill, Thomas H., Brown, Sally A., Rafols, Jose A., Shoulson, Ira·1988·Brain Research

DOI 10.1016/0006-8993(88)90124-2

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Abstract

Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morphology of medium spiny I (MSI) striatal neurons, the principal target population for both nigrostriatal and corticostriatal fibers. Our quantitative data indicate that the dendritic arbor of MSI neurons in the putamen is significantly reduced in both length and number and MSI neurons are morphologically characterized by truncated dendrites with few dendritic spines and irregular, bulbous swellings. These data provide morphological evidence for the atrophy of striatal dendrites in PD and may explain, in part, the declining efficacy of chronic L-DOPA replacement therapy in advanced PD.

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Authors: McNeill, T. H., Brown, S. A., Rafols, J. A., & Shoulson, I.
Affiliations: University of Rochester Medicine (US)
Corresponding author: McNeill, Thomas H.
ORCID: Shoulson, Ira
Venue: Brain Research
Publisher: Elsevier BV
Published: 1988-07
Volume: 455
Issue: 1
Pages: 148-152
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(88)90124-2
OpenAlex: W2069550409
Cited by: 246
References: 32
Citations by year: 2026: 1 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 9
FWCI: 3.92
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 5730 d)
Locations: Brain Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-05445, AG03644)
National Institute of Neurological Disorders and Stroke (NS17978)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Parkinson's disease, medium spiny neurons, dendritic atrophy, deafferentation, putamen, dendritic spines, substantia nigra, L-dopa therapy, neuronal morphology
MeSH terms: Aged, Aged, 80 and over, Atrophy, Corpus Striatum, Dendrites, Humans, Neurons, Parkinson Disease, Reference Values

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Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease

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