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Cited by 222Spinal Cord Injury ResearchBarrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Distribution and time course of protein extravasation in the rat spinal cord after contusive injury

Noble, L.J., Wrathall, Jean R.·1989·Brain Research
DOI 10.1016/0006-8993(89)90542-8
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Abstract

We have previously characterized a graded, spinal cord contusive injury in the rat. We have now used this reproducible model to examine vascular permeability to horseradish peroxidase (HRP) after injury. The relationship between severity of injury and distribution of protein extravasation was evaluated at 3 h after injury. After mild injury, tracer was primarily confined to central gray matter and the ventral part of the dorsal columns. After moderate injury, protein extravasation was similar to that observed after mild injury, with the exception that the central hemorrhage included pericentral while matter and occasionally extended to the pial surface. After severe injury, reaction product (RP) was more densely distributed within the central cord and peripheral white matter. The axial extent of tracer at sites proximal and distal to the impact site increased with severity of injury. At 2.0 cm from the injury, no leakage of tracer was noted after mild injury. In contrast, after moderate and severe injury limited microvascular leakage of HRP was noted. Furthermore, after severe injury, in addition to local sites of microvascular leakage, intense RP was present in the dorsal columns up to at least 2.0 cm from the injury. The time course for re-establishment of the blood-spinal cord barrier to protein was evaluated from 3 h to 14 days after moderate injury. At 3 h to 1 day, protein leakage was maximal and coincided with sites of extravasated blood components, although was consis…

Overview

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Crossref · 10.1016/0006-8993(89)90542-8

Cites

23 of 23 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. Anderson, 1983, Free radical-induced lipid peroxidation in spinal cord: FeC12 induction and protection with antioxidants, Neurochem. Pathol., 1, 249
  2. Noble, L. and Wrathall, J., Graded spinal cord contusive injuries in the rat — correlative analysis between lesion development and functional analysis,Exp. Neurol., in press.

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Metadata

Authors
Noble, L. J., & Wrathall, J. R.
Affiliations
Georgetown University (US)
Venue
Brain Research
Publisher
Elsevier BV
Published
1989-03
Volume
482
Issue
1
Pages
57-66
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(89)90542-8
OpenAlex
W2073138743
Cited by
222
References
23
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 11 · 2017: 2 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 15
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01-NS-2-3224, N01-NS-2-2310)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
spinal cord contusion, protein extravasation, blood-spinal cord barrier, vascular permeability, horseradish peroxidase tracer, microvascular leakage, hemorrhage, injury severity, dorsal columns, central gray matter, white matter, recovery time course
MeSH terms
Animals, Cell Membrane Permeability, Horseradish Peroxidase, Male, Microscopy, Electron, Nerve Tissue Proteins, Rats, Inbred Strains, Spinal Cord, Spinal Cord Injuries, Time Factors, Rats

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