Cited by 222Spinal Cord Injury ResearchBarrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

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Distribution and time course of protein extravasation in the rat spinal cord after contusive injury

Noble, L.J., Wrathall, Jean R.·1989·Brain Research

DOI 10.1016/0006-8993(89)90542-8

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Abstract

We have previously characterized a graded, spinal cord contusive injury in the rat. We have now used this reproducible model to examine vascular permeability to horseradish peroxidase (HRP) after injury. The relationship between severity of injury and distribution of protein extravasation was evaluated at 3 h after injury. After mild injury, tracer was primarily confined to central gray matter and the ventral part of the dorsal columns. After moderate injury, protein extravasation was similar to that observed after mild injury, with the exception that the central hemorrhage included pericentral while matter and occasionally extended to the pial surface. After severe injury, reaction product (RP) was more densely distributed within the central cord and peripheral white matter. The axial extent of tracer at sites proximal and distal to the impact site increased with severity of injury. At 2.0 cm from the injury, no leakage of tracer was noted after mild injury. In contrast, after moderate and severe injury limited microvascular leakage of HRP was noted. Furthermore, after severe injury, in addition to local sites of microvascular leakage, intense RP was present in the dorsal columns up to at least 2.0 cm from the injury. The time course for re-establishment of the blood-spinal cord barrier to protein was evaluated from 3 h to 14 days after moderate injury. At 3 h to 1 day, protein leakage was maximal and coincided with sites of extravasated blood components, although was consis…

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Authors: Noble, L. J., & Wrathall, J. R.
Affiliations: Georgetown University (US)
Venue: Brain Research
Publisher: Elsevier BV
Published: 1989-03
Volume: 482
Issue: 1
Pages: 57-66
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(89)90542-8
OpenAlex: W2073138743
Cited by: 222
References: 23
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 11 · 2017: 2 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 15
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01-NS-2-3224, N01-NS-2-2310)
Topics: Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: spinal cord contusion, protein extravasation, blood-spinal cord barrier, vascular permeability, horseradish peroxidase tracer, microvascular leakage, hemorrhage, injury severity, dorsal columns, central gray matter, white matter, recovery time course
MeSH terms: Animals, Cell Membrane Permeability, Horseradish Peroxidase, Male, Microscopy, Electron, Nerve Tissue Proteins, Rats, Inbred Strains, Spinal Cord, Spinal Cord Injuries, Time Factors, Rats

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Distribution and time course of protein extravasation in the rat spinal cord after contusive injury

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