Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat
Open accessAbstract
Oxytocin (OT) is a versatile neuropeptide that is involved in a variety of mammalian behaviors, and its role in reproductive function and behavior has been well established. The majority of pharmacological studies of the effects of OT on male sexual behavior have focused on the paraventricular nucleus (PVN), ventral tegmental area (VTA), hippocampus, and amygdala. Less attention has been given to the medial preoptic area (MPOA), a major integrative site for male sexual behavior. The present study investigated the effects of intra-MPOA administration of OT and (d(CH2)51, Tyr(Me)2, Thr4, Orn8, Tyr-NH29)-vasotocin, an OT antagonist (OTA), on copulation in the male rat. The relationship between OT receptor (OTR) binding levels in the MPOA and sexual efficiency was also explored. Microinjection of OT into the MPOA facilitated copulation in sexually experienced male rats, whereas similar injections of an OTA inhibited certain aspects of copulation but had no significant effect on locomotor activity in an open field. Contrary to expectation, sexually efficient males had lower levels of OTR binding in the rostral MPOA compared to inefficient animals. The present data suggest that OT activity in the MPOA is not necessary for the expression of male sexual behavior but is sufficient to facilitate copulatory behaviors and improve sexual efficiency in sexually experienced male rats. These data also suggest that OTR activity in the MPOA stimulates anogenital investigation, facilitates the initiation of copulation, and plays a role in the sensitization effect of the first ejaculation on subsequent ejaculations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
OTRs in other nuclei modulate sexual behavior in male prairie voles.
“Taken together, these data suggest that OTRs in other nuclei modulate sexual behavior in male prairie voles, consistent with findings in rats (Argiolas and Melis, 2013; Gil et al., 2011).”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Gil et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · cited 6× · see citing works
“The effects of oxytocin on myometrial and mammary myoepithelial cells are primarily mediated by the oxytocin receptor (Gimpl & Fahrenholz, 2001).”
InfluentialA stereotaxic atlas of the rat brain
Brodal, P. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90013-5 · Cited by 2,799 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · cited 5× · see citing works
“In males, these effects of vasopressin are mediated by the V1a receptor subtype, and differences in social behavior are associated with differences in the length of a microsatellite region of the gene that codes for the V1a receptor (Donaldson & Young, 2008).”
InfluentialOxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · cited 2× · see citing works
“9 intranasal administration of oxytocin decreased amygdala responses to fearful stimuli (images of faces selected because of their ability to induce a fear response in the viewer), and this decrease, according to the authors, is linked to increased sociability (Kirsch et al., 2005).”
(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03789-7 · Cited by 1,543 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 2× · see citing works
“Oxytocinergic afferents in the NAcc are believed to originate from neurons in the hypothalamus (Young & Wang, 2004).”
NEWMAN, S. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09271.x · Cited by 1,189 · cited 10× · see citing works
“It should be noted that both male sexual behavior and maternal behavior are regulated by a similar chemosensory circuit, which includes the MeA, BNST, and the MPOA.”
InfluentialOxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · cited 4× · see citing works
“And surely one of the most insightful descriptions of oxytocin was provided by Lee et al. (2009) who described oxytocin as “the great facilitator of life.””
InfluentialOxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770 · cited 1× · see citing works
“Florida State University Libraries Electronic Theses, Treatises and Dissertations The Graduate School 2010 Oxytocin in the Medial Preoptic Area Facilitates Male Sexual Behavior in the Rat Mario Gil Follow this and additional works at the FSU Digital Library.”
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743 · cited 5× · see citing works
“In both male and female rats, infusion of oxytocin into the brain decreases anxiety-like behaviors (Neumann, 2008).”
InfluentialChampagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707 · cited 2× · see citing works
“In female rats, there is a positive relationship between OTR binding in the MPOA and maternal licking and grooming and responsivity to pups (Champagne et al., 2001; Francis et al., 2000).”
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · cited 3× · see citing works
“…et al., 1989; Pedersen et al., 1992); promotes social recognition in rats (Neumann, 2008); facilitates partner preference formation in prairie voles (Insel, 2003); and there is growing evidence suggesting a link between central oxytocin dysfunction and autism in humans (Hollander et al., 2007).”
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595 · see citing works
Simerly, R. B., & Swanson, L. W. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902700205 · Cited by 592 · cited 1× · see citing works
“This contention is supported by the fact that the MPOA is reciprocally connected to various neural sites, including the PVN, MeA, PAG, and nPGI (McKenna, 2000; Simerly & Swanson, 1988).”
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 3× · see citing works
“Mating-induced partner preference can be disrupted by intracerebroventricular (i.c.v.) administration of an oxytocin antagonist, whereas an oxytocin agonist promotes this behavior in the absence of copulation (Lim et al., 2004; Liu & Wang, 2003).”
InfluentialPlasma oxytocin increases in the human sexual response
CARMICHAEL, M. S., HUMBERT, R., DIXEN, J., PALMISANO, G., GREENLEAF, W., & DAVIDSON, J. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-27 · Cited by 554 · cited 2× · see citing works
“Plasma concentrations of oxytocin increase during the sexual response in rats and humans (Carmichael et al., 1987; Stoneham, Everitt, Hansen, Lightman, & Todd, 1985).”
The organization of neural inputs to the medial preoptic nucleus of the rat
Simerly, R. B., & Swanson, L. W. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902460304 · Cited by 523 · cited 1× · see citing works
“These reciprocal connections suggest that the MPOA is capable of receiving information regarding sexually relevant cues and influencing the processing of these cues (Hull, Meisel, & Sachs, 2002; Simerly & Swanson, 1986).”
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496 · cited 3× · see citing works
“Specifically, oxytocin receptor levels are higher in high LG mothers than in low LG mothers (Francis et al., 2000).”
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475 · see citing works
Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Eriksson, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803081105 · Cited by 460 · cited 1× · see citing works
“Specifically, men with a particular polymorphism of the avpr1a gene reported significantly more marital problems and were more likely to be in a nonmarried relationship compared to men who had different avpr1a polymorphisms (Walum et al., 2008).”
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Is social attachment an addictive disorder?
Insel, T. R. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00148-3 · Cited by 430 · cited 8× · see citing works
“In female prairie voles, the formation of a pair bond is dependent on a similar transition from avoidance to selective motivation to be with a specific individual (Insel, 2003).”
InfluentialThe neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Tomizawa, K., Iga, N., Lü, Y.-F., Moriwaki, A., Matsushita, M., Li, S., Miyamoto, O., Itano, T., & Matsui, H. (2003) · Nature Neuroscience · doi:10.1038/nn1023 · Cited by 372 · cited 2× · see citing works
“Thus, Tomizawa et al. (2003) hypothesized that oxytocin is involved in the facilitation of spatial memory by maternal experience.”
Hull, E. M., & Rodrı́guez–Manzo, G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00001-2 · Cited by 371 · see citing works
Damsma, G., Pfaus, J. G., Wenkstern, D., Phillips, A. G., & al, E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.181 · Cited by 370 · see citing works
Argiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 364 · cited 2× · see citing works
“Infusion of nanogram (ng) amounts of oxytocin into the lateral ventricles stimulates copulation in male rats (Argiolas & Gessa, 1991; Arletti, Bazzani, Castelli, & Bertolini, 1985).”
Numan, M., & Stolzenberg, D. S. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.002 · Cited by 361 · cited 7× · see citing works
“And there is growing evidence that oxytocin is a key player in this interaction (Melis et al., 2007; Numan & Stolzenberg, 2009; Succu et al., 2007).”
InfluentialOxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352 · see citing works
Gingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339 · cited 6× · see citing works
“Dopamine exerts its effects by binding to D2-like receptors in the NAcc (Gingrich et al., 2000; Wang et al., 1999).”
InfluentialHull, E. M., Du, J., Lorrain, D., & Matuszewich, L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07465.1995 · Cited by 321 · see citing works
Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.
Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.5.727 · Cited by 320 · see citing works
Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat
Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.727 · Cited by 320 · cited 1× · see citing works
“This interpretation of the data is consistent with previous findings that the MPOA is involved in sexual motivation (Kleitz-Nelson et al., 2010; Pfaus and Phillips, 1991; Warner et al., 1991).”
Zingg, H. H., & Laporte, S. A. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00080-8 · Cited by 316 · cited 9× · see citing works
“Most of these receptors stimulate Gq/11, a G protein that activates phospholipase C (PLC) (Zingg & Laporte, 2003).”
InfluentialMotherhood improves learning and memory
Kinsley, C. H., Madonia, L., Gifford, G. W., Tureski, K., Griffin, G. R., Lowry, C., Williams, J., Collins, J., McLearie, H., & Lambert, K. G. (1999) · Nature · doi:10.1038/45957 · Cited by 297 · cited 1× · see citing works
“It was found that female rats with maternal experience performed significantly better than virgin females on two types of spatial memory tests (Kinsley et al., 1999).”
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
Brain Architecture: Understanding the Basic Plan
Swanson, L. W. (2002) · Cited by 273 · see citing works
Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats
Pfaus, J. G., Damsma, G., Wenkstern, D., & Fibiger, H. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00679-k · Cited by 236 · see citing works
Expression of oxytocin receptor in human pregnant myometrium
Kimura, T., Takemura, M., Nomura, S., Nobunaga, T., Kubota, Y., Inoue, T., Hashimoto, K., KUMAZAWA, I., Ito, Y., Ohashi, K., et al. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593830 · Cited by 222 · cited 2× · see citing works
“As stated previously, oxytocin receptors are present in the peripheral reproductive systems of both men and women (Kimura et al., 1996; Vignozzi et al., 2004; Vignozzi et al., 2008).”
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 215 · cited 4× · see citing works
“…is released at 6 the time of parturition, which promotes maternal behavior (e.g., motivation to be with pups) as well as the physiological changes that are needed for parturition and maternal care (Keverne & Curley, 2004; Pedersen, 1997; Pedersen, Caldwell, Peterson, Walker, & Mason, 1992).”
InfluentialDopaminergic control of male sex behavior in rats: Effects of an intracerebrally-infused agonist
Hull, E. M., Bitran, D., Pehek, E. A., Warner, R. K., Band, L. C., & Holmes, G. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91106-6 · Cited by 211 · cited 1× · see citing works
“In fact, we now have a well supported hypothesis of how dopamine and its receptors in the MPOA facilitate male sexual behavior in the rat (Hull et al., 1986; Hull, Du, Lorrain, & Matuszewich, 1995; Hull et al., 1992).”
Organization and regulation of sexually dimorphic neuroendocrine pathways
Simerly, R. B. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00191-5 · Cited by 201 · cited 2× · see citing works
“The rostral MPOA contains the anteroventral periventricular nucleus (AVPV), which is a sexually dimorphic area that is larger in females (Simerly, 1998).”
Melis, M. R., Melis, T., Cocco, C., Succu, S., Sanna, F., Pillolla, G., Boi, A., Ferri, G., & Argiolas, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05721.x · Cited by 198 · cited 5× · see citing works
“Oxytocin infused into the VTA also stimulates penile erection and increases dopamine levels in the NAcc of male rats (Melis et al., 2007).”
InfluentialOxytocin-induced penile erection and yawning: site of action in the brain
Melis, M. R., Argiolas, A., & Gessa, G. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91485-x · Cited by 190 · cited 4× · see citing works
“, 1985); these effects are dependent, in part, on stimulation of OTRs in the PVN and CA1 region of the hippocampus (Melis et al., 1986).”
InfluentialThe role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals
Argiolas, A., & Melis, M. R. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.019 · Cited by 177 · cited 7× · see citing works
“In fact, oxytocin-induced erections are blocked by Ca2+–channel blockers (Argiolas & Melis, 2004).”
InfluentialOxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimuli<sup>a</sup>
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172 · cited 2× · see citing works
“, motivation to be with pups) as well as the physiological changes that are needed for parturition and maternal care (Keverne & Curley, 2004; Pedersen, 1997; Pedersen, Caldwell, Peterson, Walker, & Mason, 1992).”
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
Burri, A., Heinrichs, M., Schedlowski, M., & Kruger, T. H. C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.014 · Cited by 168 · see citing works
Oxytocin and sexual behaviour in the male rat and rabbit
Stoneham, M. D., Everitt, B. J., Hansen, S., Lightman, S. L., & Todd, K. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1070097 · Cited by 160 · cited 2× · see citing works
“Plasma concentrations of OT increase during the sexual response in rats and humans (Carmichael et al., 1987; Stoneham et al., 1985); and a link between sexual impotence and reduced central OT production has been established in the male rat (Arletti et al.”
Lodish, H. F. (2003) · Cited by 159 · see citing works
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156 · see citing works
Oxytocin improves male copulatory performance in rats
Arletti, R., Bazzani, C., Castelli, M., & Bertolini, A. (1985) · Hormones and Behavior · doi:10.1016/0018-506x(85)90002-9 · Cited by 155 · cited 2× · see citing works
“Specifically, oxytocin treatment shortens ejaculation latency and the postejaculatory interval (Arletti et al., 1985).”
Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat.
Freund‐Mercier, M. J., Stoeckel, M. E., & Klein, M. J. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020349 · Cited by 153 · cited 1× · see citing works
“In addition, in female rats, OTR binding in the PVN is dramatically reduced during lactation, and this, the authors suggest, is likely due to receptor down-regulation caused by high levels of OT in lactating rats (Freund-Mercier et al., 1994; Gimpl and Fahrenholz, 2001).”
Structure, function, and phylogeny of [Arg8]vasotocinreceptors from teleost fish and toad.
Mahlmann, S., Meyerhof, W., Hausmann, H., Heierhorst, J., Schönrock, C., Zwiers, H., Lederis, K. P., & Richter, D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1342 · Cited by 151 · cited 2× · see citing works
“Oxytocin belongs to a highly conserved family of peptides that has a long history of regulating reproductive behaviors in vertebrates (Boyd, 1997; Mahlmann et al., 1994).”
Adan, R. A., Van Leeuwen, F. W., Sonnemans, M. A., Brouns, M., Hoffman, G., Verbalis, J. G., & Burbach, J. P. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649111 · Cited by 147 · cited 1× · see citing works
“However, there is research suggesting that other oxytocin receptor subtypes may also exist (Adan et al., 1995).”
Ku, C.-Y., Qian, A., Wen, Y., Anwer, K., & Sanborn, B. M. (1995) · Endocrinology · doi:10.1210/endo.136.4.7895660 · Cited by 146 · see citing works
Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat
Véronneau-Longueville, F., Rampin, O., Freund‐Mercier, M. J., Tang, Y., Calas, A., Marson, L., McKenna, K. E., Stoeckel, M. E., Benoît, G., & Giuliano, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00262-6 · Cited by 140 · cited 1× · see citing works
“In addition, OT binding sites and varicosities have been identified in thoracolumbar and lumbosacral spinal segments that control penile erection in rats, and OTR is expressed in penile tissue inmen (Veronneau-Longueville et al., 1999; Vignozzi et al., 2004).”
Tenk, C. M., Wilson, H., Zhang, Q., Pitchers, K. K., & Coolen, L. M. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.08.012 · Cited by 136 · see citing works
Wang, Z., Liu, Y., Young, L. J., & Insel, T. R. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00435.x · Cited by 134 · cited 1× · see citing works
“Tissue containingMPOAwas collected and processed for OTR autoradiographic binding using an established method (Wang et al., 2000).”
MethodHull, E. M., Eaton, R. C., Markowski, V. P., Moses, J., Lumley, L. A., & Loucks, J. A. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90299-5 · Cited by 130 · cited 1× · see citing works
“In fact, we now have a well supported hypothesis of how dopamine and its receptors in the MPOA facilitate male sexual behavior in the rat (Hull et al., 1986; Hull, Du, Lorrain, & Matuszewich, 1995; Hull et al., 1992).”
Sachs, B. D. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00022-1 · Cited by 129 · see citing works
The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Argiolas, A., Collu, M., Gessa, G. L., Melis, M. R., & Serra, G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90675-9 · Cited by 125 · cited 4× · see citing works
“Intracerebroventricular (icv) administration of an OTA increases intromission and ejaculation latencies and decreases mounts and intromissions (Argiolas et al., 1988).”
InfluentialChronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin
Cantor, J. M., Binik, Y. M., & Pfaus, J. G. (1999) · Psychopharmacology · doi:10.1007/s002130051018 · Cited by 122 · cited 1× · see citing works
“OT can also restore copulation in males whose copulatory behavior had been impaired by chronic fluoxetine (Cantor et al., 1999).”
NEUROPLASTICITY IN THE MESOLIMBIC SYSTEM INDUCED BY NATURAL REWARD AND SUBSEQUENT REWARD ABSTINENCE
Pitchers, K., Balfour, M., Lehman, M., Richtand, N., Yu, L., & Coolen, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.036 · Cited by 118 · cited 1× · see citing works
“In fact, copulation induces morphological changes in the mesolimbic dopamine system, a system that is important for motivation and reward (Pitchers et al., 2009).”
Succu, S., Sanna, F., Melis, T., Boi, A., Argiolas, A., & Melis, M. R. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.10.019 · Cited by 117 · cited 3× · see citing works
“And there is growing evidence that oxytocin is a key player in this interaction (Melis et al., 2007; Numan & Stolzenberg, 2009; Succu et al., 2007).”
Stimulation of the hypothamus initiates the urethrogenital reflex in male rats
Marson, L., & McKenna, K. E. (1994) · Brain Research · doi:10.1016/0006-8993(94)90638-6 · Cited by 116 · see citing works
Warner, R. K., Thompson, J. T., Markowski, V. P., Loucks, J. A., Bazzett, T. J., Eaton, R. C., & Hull, E. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90505-p · Cited by 115 · cited 2× · see citing works
“Of course, it has already been shown that dopamine neurotransmission in the MPOA plays a role in sexual motivation in male rats (Warner et al., 1991).”
Popik, P., & van Ree, J. M. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90010-r · Cited by 114 · see citing works
Conceptual and Neural Mechanisms of Masculine Copulatory Behavior
Sachs, B. D. (1978) · Springer eBooks · doi:10.1007/978-1-4899-0421-8_10 · Cited by 112 · see citing works
Regulation by the Medial Amygdala of Copulation and Medial Preoptic Dopamine Release
Dominguez, J. M., Riolo, J. V., Xu, Z., & Hull, E. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00349.2001 · Cited by 111 · see citing works
Medial preoptic area oxytocin and female sexual receptivity.
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., & Pedersen, C. A. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.3.655 · Cited by 110 · cited 2× · see citing works
“Florida State University Libraries Electronic Theses, Treatises and Dissertations The Graduate School 2010 Oxytocin in the Medial Preoptic Area Facilitates Male Sexual Behavior in the Rat Mario Gil Follow this and additional works at the FSU Digital Library.”
Synaptic plasticity: A role for nitric oxide in LTP
Huang, E. P. (1997) · Current Biology · doi:10.1016/s0960-9822(97)70073-3 · Cited by 110 · cited 1× · see citing works
“NO plays an important role in long-term potentiation (LTP) in the hippocampus, and researchers hypothesize that LTP is important for memory formation (Huang, 1997).”
Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
Mühlethaler, M., Sawyer, W. H., Manning, M., & Dreifuss, J. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.21.6713 · Cited by 106 · see citing works
Oxytocin Activation of Maternal Behavior in the Rata
Pedersen, C. A., Caldwell, J. D., Peterson, G. W., Walker, C. H., & Mason, G. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34346.x · Cited by 106 · cited 1× · see citing works
“To name a few examples, oxytocin plays a role in female reproductive behavior in rats (Caldwell et al., 1989; Pedersen et al., 1992); promotes social recognition in rats (Neumann, 2008); facilitates partner preference formation in prairie voles (Insel, 2003); and there is growing evidence…”
Dopamine–oxytocin interactions in penile erection
Baskerville, T. A., Allard, J., Wayman, C., & Douglas, A. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06999.x · Cited by 105 · cited 5× · see citing works
“, 1992), and OT-containingMPOA neurons are activated (Fos-ir) by copulation (Baskerville et al., 2009).”
InfluentialIncreased Fos Expression in Oxytocin Neurons Following Masculine Sexual Behavior
Witt, D. M., & Insel, T. R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00549.x · Cited by 102 · cited 1× · see citing works
“, Fos-immunoreactive, -ir) following copulation (Witt and Insel, 1994) or ex copula non-contact erections (Baskerville et al.”
The development of olfactory conditioned ejaculatory preferences in the male rat
Kippin, T. E., & Pfaus, J. G. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00484-x · Cited by 93 · cited 2× · see citing works
“…to ejaculation with one female and then paired with a different scented female during the refractory period that follows an ejaculation, the male develops a preference for a scented female that has the same odor that was previously associated with the refractory period (Kippin & Pfaus, 2001).”
Medial preoptic area oxytocin and female sexual receptivity.
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., et al. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.3.655 · Cited by 92 · see citing works
Preoptic Glutamate Facilitates Male Sexual Behavior
Dominguez, J. M., Gil, M., & Hull, E. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4176-05.2006 · Cited by 91 · see citing works
Some proposals regarding the organization of the central nervous system control of penile erection
McKenna, K. E. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00021-x · Cited by 79 · cited 14× · see citing works
“14 The nPGI of the rostral medulla is a source of tonic inhibition of spinal sexual reflexes, and the major transmitter produced by cells in this area is serotonin (McKenna, 2000).”
InfluentialMelis, M. R., Spano, M. S., Succu, S., & Argiolas, A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00236-0 · Cited by 72 · cited 1× · see citing works
“OTA treatment (icv) reduces non-contact erections in the presence of a receptive female (Melis et al., 1999), and intraperitoneal (ip) injections of OT stimulate the onset of copulation in aging (20-month old) male rats (Arletti et al.”
Melis, M. R., Succu, S., Sanna, F., Boi, A., & Argiolas, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06912.x · Cited by 72 · see citing works
Brain Vasotocin Pathways and the Control of Sexual Behaviors in the Bullfrog
Boyd, S. K. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00213-x · Cited by 71 · cited 2× · see citing works
“Oxytocin belongs to a highly conserved family of peptides that has a long history of regulating reproductive behaviors in vertebrates (Boyd, 1997; Mahlmann et al., 1994).”
Vignozzi, L., Filippi, S., Luconi, M., Morelli, A., Mancina, R., Marini, M., Vannelli, G. B., Granchi, S., Orlando, C., Gelmini, S., et al. (2003) · Endocrinology · doi:10.1210/en.2003-0962 · Cited by 70 · cited 3× · see citing works
“Oxytocin receptors have been identified in the male reproductive tract (e.g., penis, testes, prostate gland) in several species, including humans (Gimpl & Fahrenholz, 2001; Vignozzi et al., 2004).”
Vignozzi, L., Filippi, S., Morelli, A., Luconi, M., Jannini, E. A., Forti, G., & Maggi, M. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00914.x · Cited by 69 · cited 1× · see citing works
“As stated previously, oxytocin receptors are present in the peripheral reproductive systems of both men and women (Kimura et al., 1996; Vignozzi et al., 2004; Vignozzi et al., 2008).”
Succu, S., Sanna, F., Cocco, C., Melis, T., Boi, A., Ferri, G., Argiolas, A., & Melis, M. R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06385.x · Cited by 69 · see citing works
Oxytocin Involvement in Male and Female Sexual Behavior
Arletti, R., Benelli, A., & Bertolini, A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34354.x · Cited by 66 · cited 2× · see citing works
“, 1985); these effects are blocked by pretreatment with an OT receptor (OTR) antagonist (OTA) (Arletti et al., 1992).”
Gupta, J., Russell, R. J., Wayman, C. P., Hurley, D., & Jackson, V. M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.226 · Cited by 66 · see citing works
Caldwell, J. D., Johns, J. M., Faggin, B. M., Senger, M., & Pendersen, C. A. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1024 · Cited by 63 · see citing works
Sexual behavior of aging male rats is stimulated by oxytocin
Arletti, R., Benelli, A., & Bertolini, A. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90178-9 · Cited by 53 · cited 1× · see citing works
“For more information, please contact lib-ir@fsu.edu”
Lagoda, G. A., Muschamp, J. W., Vigdorchik, A. V., & Hull, E. M. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1317 · Cited by 53 · see citing works
Is sexual motivational state linked to dopamine release in the medial preoptic area?
Kleitz‐Nelson, H. K., Dominguez, J. M., Cornil, C. A., & Ball, G. F. (2010) · Behavioral Neuroscience · doi:10.1037/a0018767 · Cited by 51 · cited 1× · see citing works
“This interpretation of the data is consistent with previous findings that the MPOA is involved in sexual motivation (Kleitz-Nelson et al., 2010; Pfaus and Phillips, 1991; Warner et al., 1991).”
Marson, L. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.026 · Cited by 51 · cited 7× · see citing works
“This contention is supported by the fact that the MPOA is reciprocally connected to various neural sites, including the PVN, MeA, PAG, and nPGI (McKenna, 2000; Simerly & Swanson, 1988).”
InfluentialIntraventricular oxytoxin induces yawning and penile erection in rats
Argiolas, A., Melis, M. R., & Gessa, G. L. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90018-4 · Cited by 50 · cited 1× · see citing works
“OT treatment (icv) induces ex copula penile erection in male rats (Argiolas et al., 1985); these effects are dependent, in part, on stimulation of OTRs in the PVN and CA1 region of the hippocampus (Melis et al.”
Arletti, R., Calzà, L., Giardino, L., Benelli, A., Cavazzuti, E., & Bertolini, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00478-3 · Cited by 46 · cited 5× · see citing works
“, 1985); and a link between sexual impotence and reduced central OT production has been established in the male rat (Arletti et al., 1997).”
InfluentialPowell, W. S., Dominguez, J. M., & Hull, E. M. (2003) · Behavioral Neuroscience · doi:10.1037//0735-7044.117.1.69 · Cited by 43 · see citing works
Sexual experience increases nitric oxide synthase in the medial preoptic area of male rats.
Dominguez, J. M., Brann, J. H., Gil, M., & Hull, E. M. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1389 · Cited by 41 · see citing works
Gelez, H., Poirier, S., Facchinetti, P., Allers, K. A., Wayman, C. P., Alexandre, L., & Giuliano, F. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01760.x · Cited by 35 · cited 1× · see citing works
“In female rats, a few OT-ir neurons in the MPOA project indirectly to the clitoris and vagina, suggesting a role for OT in the MPOA in the control of sexual function in females (Gelez et al., 2010).”
Manning, M., Cheng, L., Stoev, S. B., Wo, N. C., Chan, W. Y., Szeto, H. H., Durroux, T., Mouillac, B., & Barberis, C. (2005) · Journal of Peptide Science · doi:10.1002/psc.667 · Cited by 31 · cited 1× · see citing works
“The OTA used in Experiments Two and Three is indeed a potent antagonist of the oxytocin receptor, but it can also bind to vasopressin receptors (Manning et al., 2005).”
Behavioral neurochemistry, neuroendocrinology and molecular neurobiology
Blaustein, D. J., & Lajtha, Á. (2007) · Springer eBooks · Cited by 29 · see citing works
(1978) · Springer eBooks · doi:10.1007/978-1-4899-0421-8 · Cited by 28 · see citing works
Neurohypophysial peptides: gatekeepers in the amygdala
Pittman, Q. J., & Spencer, S. J. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.08.001 · Cited by 15 · cited 2× · see citing works
“For example, oxytocin has been described as a “gatekeeper” for its role in regulating autonomic and emotional responses (Pittman & Spencer, 2005).”
Neurochemistry of Male Sexual Behavior
Hull, E. M., Dominguez, J. M., & Muschamp, J. W. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_2 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Hull, E. M., & Rodrı́guez–Manzo, G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00001-2 · Cited by 371 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
“Finally, in the medial preoptic area, OT release facilitates and 5-HT release inhibits male sexual behavior (Dominguez and Hull, 2010; Gil et al., 2011).”
BackgroundNeuropeptides and central control of sexual behaviour from the past to the present: A review
Argiolas, A., & Melis, M. R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.006 · Cited by 141 · see citing works
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Qian, T., Wang, H., Wang, P., Geng, L., Mei, L., Osakada, T., Wang, L. A., Tang, Y., Kania, A., Grinevich, V., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01561-2 · Cited by 145 · see citing works
“OT has been reported to have a role in male mating behaviors 59–65 .”
BackgroundHarari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 135 · see citing works
Oxytocin and Estrogen Receptor β in the Brain: An Overview
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00160 · Cited by 124 · see citing works
“Central OT is important in homeostatic processes, such as thermoregulation (9), food intake (10), and mating (11, 12).”
BackgroundNeural mechanisms of sexual behavior in the male rat: Emphasis on ejaculation-related circuits
Veening, J. G., & Coolen, L. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.017 · Cited by 121 · see citing works
Oxytocin receptors modulate a social salience neural network in male prairie voles
Johnson, Z. V., Walum, H., Xiao, Y., Riefkohl, P. C., & Young, L. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.009 · Cited by 113 · see citing works
“Taken together, these data suggest that OTRs in other nuclei modulate sexual behavior in male prairie voles, consistent with findings in rats (Argiolas and Melis, 2013; Gil et al., 2011).”
Vasopressin, oxytocin, and social odor recognition
Wacker, D. W., & Ludwig, M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.014 · Cited by 112 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
“In male rats oxy facilitates copulation, when injected into the medial preoptic area and this effect is abolished by the pre-administration of an oxyr antagonist (Gil et al., 2011).”
BackgroundAntiaggressive activity of central oxytocin in male rats
Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3124-7 · Cited by 90 · see citing works
Rebalancing the Addicted Brain: Oxytocin Interference with the Neural Substrates of Addiction
Bowen, M. T., & Neumann, I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.003 · Cited by 83 · see citing works
“Given that increased OXTR expression has been repeatedly associated with decreased OXT levels, it has been hypothesised that the increased receptor expression may be a compensatory response to reduced ligand levels [43,61,64].”
Kudwa, A. E., McGivern, R. F., & Handa, R. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.004 · Cited by 73 · see citing works
“Although OVT has been previously reported to not influence locomotor activity when delivered to the medial preoptic area [59], it is still possible that there is an overall effect of OVT in these studies that could counter the effects of R-DPN.”
BackgroundSerotonin 1A receptors and sexual behavior in female rats: A review
Snoeren, E. M. S., Veening, J. G., Olivier, B., & Oosting, R. S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.017 · Cited by 65 · see citing works
Mate-choice copying, social information processing, and the roles of oxytocin
Kavaliers, M., Matta, R., & Choleris, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.003 · Cited by 60 · see citing works
“In addition, there is substantial evidence for OT involvement in sexual performance and the facilitation of female and male sexual behaviors (e.g., Argiolas and Melis, 2004; Carter, 1992; Gil et al., 2011; McCarthy et al., 1994; Veening et al., 2015).”
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
“In the MPOA, OXT administration facilitates both sexual behavior (Gil et al., 2011) and social recognition (Popik & van Ree, 1991) in adult male rats.”
MethodSerotonin 1A receptors and sexual behavior in male rats: A review
Snoeren, E. M. S., Veening, J. G., Olivier, B., & Oosting, R. S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.007 · Cited by 58 · see citing works
“In addition, injections of oxytocin in for instance the MPOA facilitated copulation in sexually experience males (Gil et al., 2011, 2013).”
BackgroundErectile Dysfunction: Treatments, Advances and New Therapeutic Strategies
Argiolas, A., Argiolas, F. M., Argiolas, G., & Melis, M. R. (2023) · Brain Sciences · doi:10.3390/brainsci13050802 · Cited by 55 · see citing works
Waldinger, M. D. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.004 · Cited by 51 · see citing works
Gil, M., Bhatt, R., Picotte, K. B., & Hull, E. M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.002 · Cited by 50 · see citing works
“We previously reported that intra-MPOA OTA decreases anogenital investigation (AGI) and delays the initiation of copulation in sexually experienced male rats (Gil et al., 2011).”
BackgroundInfluentialOxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
The drug treatment of delayed ejaculation
Abdel‐Hamid, I. A., Elsaied, M. A., & Mostafa, T. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.05.05 · Cited by 44 · see citing works
“(112-116); (IV) the pro-ejaculatory effects of systemic OT may be mediated via actions on peripheral OT or vasopressin (AVP) receptors that have been demonstrated in the testis, epididymis, vas deferens, prostate and penis of humans and animals , where they regulate the contractility of smooth muscle cells involved in…”
BackgroundOxytocin enhances the expression of morphine-induced conditioned place preference in rats
Moaddab, M., Hyland, B. I., & Brown, C. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.003 · Cited by 41 · see citing works
The role of ghrelin signalling for sexual behaviour in male mice
Egecioglu, E., Prieto‐Garcia, L., Studer, E., Westberg, L., & Jerlhag, E. (2014) · Addiction Biology · doi:10.1111/adb.12202 · Cited by 31 · see citing works
“Supportively, oxytocin locally injected into the MPOA does not affect sexual motivation but facilitates copulatory behaviours and improves sexual efficiency in sexually experienced male rats (Gil et al. 2011).”
BackgroundMcMahon, C., Althof, S. E., Rosen, R. C., Giuliano, F., Miner, M. M., Osterloh, I. H., Muirhead, G. J., & Harty, B. J. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.05.016 · Cited by 29 · see citing works
Current and Emerging Treatments for Premature Ejaculation
McMahon, C. G. (2015) · Sexual Medicine Reviews · doi:10.1002/smrj.49 · Cited by 27 · see citing works
Emerging and investigational drugs for premature ejaculation
McMahon, C. G. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.04.02 · Cited by 26 · see citing works
“Several authors report that copulatory behavior/ejaculation activates oxytocin neurons in rodent brain regions (140,141).”
BackgroundLópez, H. S., Agustín‐Pavón, C., Lanuza, E., & Martínez‐Garciá, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208960 · Cited by 25 · see citing works
Administration of an oxytocin receptor antagonist attenuates sexual motivation in male rats
Blitzer, D. S., Wells, T. E., & Hawley, W. R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.002 · Cited by 25 · see citing works
“Contrary to the results indicated above that OT in the MPOA is involved in sexual motivation (Gil et al., 2011), past research indicated that lesions of the MPOA do not affect male rat sexual motivation, as measured by lever pressing behavior to a conditioned stimulus in order to gain access to a…”
InfluentialMating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
Phan, J., Alhassen, L., Argelagos, A., Alhassen, W., Vachirakorntong, B., Lin, Z., Sanathara, N. M., & Alachkar, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-70667-x · Cited by 24 · see citing works
Nutsch, V. L., Will, R. G., Robison, C. L., Martz, J. R., Tobiansky, D. J., & Dominguez, J. M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00075 · Cited by 24 · see citing works
Hull, E. M., & Dominguez, J. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00049-1 · Cited by 24 · see citing works
Hull, E. M., & Rodrı́guez–Manzo, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00001-8 · Cited by 24 · see citing works
Sanna, F., Piludu, M. A., Corda, M. G., Argiolas, A., Giorgi, O., & Melis, M. R. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.012 · Cited by 22 · see citing works
“…with several other neurotransmitter systems such as excitatory and inhibitory amino acids, nitric oxide, oxytocin and opioid peptides (Argiolas and Melis, 1995, 2005, 2013; Melis and Argiolas, 1995, 2011; Hull et al., 1991, 1995, 1999, 2002; Gil et al., 2011; Moses et al., 1995; McKenna, 2000).”
BackgroundFreeman, A. R., Aulino, E. A., Caldwell, H. K., & Ophir, A. G. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12828 · Cited by 19 · see citing works
Sanna, F., Bratzu, J., Argiolas, A., & Melis, M. R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.004 · Cited by 17 · see citing works
“…accompanied by the wellknown facilitatory effects of oxytocin on erectile function and sexual behavior (see Argiolas and Melis, 2004, 2005, 2013; Gil et al., 2011, 2013) suggest that a PVN-BNST neural pathway may be involved in the sexual effects that occur after stimulation or lesioning of the…”
BackgroundSakata, J. T., Catalano, I., & Woolley, S. C. (2021) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2539 · Cited by 11 · see citing works
Dhungel, S., Rai, D., Terada, M., Orikasa, C., Nishimori, K., Sakuma, Y., & Kondo, Y. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.11.008 · Cited by 14 · see citing works
Sauer, C., Montag, C., Reuter, M., & Kirsch, P. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.06.005 · Cited by 13 · see citing works
Osterloh, I. H., Muirhead, G. J., Sultana, S. R., Steven, W., van den Berg, F., & Atiee, G. J. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.09.006 · Cited by 13 · see citing works
Moderate Role of Oxytocin in the Pro-Ejaculatory Effect of the 5-HT1A Receptor Agonist 8-OH-DPAT
A, T. R. D. J., & Neumann, I. D. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12742 · Cited by 13 · see citing works
Prenatal Hypoxia Ischemia Increases Male Rat Sexual Behavior
Ferraz, M. M. D., Sab, I. M., Silva, M. A., Santos, D. A. S., & Ferraz, M. R. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.13006 · Cited by 13 · see citing works
Shindel, A. W., Şerefoğlu, E. C., Althof, S. E., Arafa, M., Bhat, G. S., Snoeren, E. M. S., Zhang, Y., & El-Meliegy, A. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf016 · Cited by 12 · see citing works
Estrada‐Reyes, R., Dorantes‐Barrón, A. M., Arrieta‐Báez, D., Gómez‐Patiño, M. B., Bernal-Trujillo, A., Castro-García, M., Carro-Juárez, M., & Martı́nez-Mota, L. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.10.030 · Cited by 12 · see citing works
Bratzu, J., Bharatiya, R., Manca, E., Cocco, C., Argiolas, A., Melis, M. R., & Sanna, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112147 · Cited by 12 · see citing works
Hypothalamic cellular and molecular plasticity linked to sexual experience in male rats and mice
Jean, A., Mhaouty‐Kodja, S., & Hardin‐Pouzet, H. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100949 · Cited by 10 · see citing works
Freeman, A. R., Hare, J. F., & Caldwell, H. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24400 · Cited by 10 · see citing works
Manjila, S. B., Betty, R., & Kim, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1044736 · Cited by 11 · see citing works
“Intracerebral injections of Oxt in the MPO resulted in increased sexual behavior in male rats (Gil et al., 2011) and increased sexual receptivity in female rats (Caldwell et al.”
BackgroundMelis, M. R., Sanna, F., & Argiolas, A. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0058 · Cited by 9 · see citing works
“Among these, the most studied are the medial preoptic area (see Hull et al., 1995, 2004; Hull and Dominguez, 2006, 2007; Gil et al., 2011, 2013), the paraventricular nucleus of the hypothalamus (see Argiolas and Melis, 1995, 2005, 2013; Melis and Argiolas, 1995, 2002, 2003, 2011), the ventral…”
BackgroundMaejima, S., Abe, Y., Yamaguchi, S., Musatov, S. A., Ogawa, S., Kondo, Y., & Tsukahara, S. (2018) · Endocrinology · doi:10.1210/en.2018-00804 · Cited by 9 · see citing works
Oxytocin mediates copulation-induced hypoalgesia of male rats
Futagami, H., Sakuma, Y., & Kondo, Y. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.007 · Cited by 7 · see citing works
Nutsch, V. L., Bell, M. R., Will, R. G., Yin, W., Wolfe, A., Gillette, R., Dominguez, J. M., & Gore, A. C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.023 · Cited by 6 · see citing works
“Oxytocin in the POA facilitates sexual behavior inmales, and this undergoes age-related impairments (Gil et al., 2011).”
BackgroundTurner, J. M., Will, R. G., Harvey, E. A., Hattori, T., Tobiansky, D. J., Nutsch, V. L., Martz, J. R., & Dominguez, J. M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112006 · Cited by 7 · see citing works
“In males, sexual experience increases expression of numerous functionally important peptides within the mPOA, including oxytocin receptor [29]; phosphorylated DARPP-32, an integrator of cAMP and Ca2+ signaling [30]; androgen receptors in male mice [31]; and nitric oxide synthase in male rats [32].”
BackgroundMénard, S., Gelez, H., Coria‐Ávila, G. A., & Pfaus, J. G. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105900 · Cited by 7 · see citing works
Microbial Muses: Threads of Our Inner Wisdom
Erdman, S. E. (2021) · Challenges · doi:10.3390/challe12010010 · Cited by 6 · see citing works
“To the same extent, virginal male rats miraculously make better lovers after an oxytocin-drip, even though they have never watched a video [6].”
BackgroundBogus‐Nowakowska, K., Litwin, D., Robak, A., Równiak, M., Żakowski, W., Wasilewska, B., Najdzion, J., & Milewski, S. (2012) · Journal of Veterinary Research · doi:10.2478/v10213-012-0062-9 · Cited by 6 · see citing works
“For example, classical neurotransmitters like: dopamine (10), γ-aminobutyric acid (34), as well as gonadotropin-releasing hormon e (19), oxytocin (9), or aromatase (23).”
Damián, J. P., Hötzel, M. J., Banchero, G. E., & Ungerfeld, R. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.06.009 · Cited by 7 · see citing works
Garduño‐Gutierrez, R., Rodrı́guez–Manzo, G., Velázquez-Alvarado, A., Miller-Pérez, C., & León‐Olea, M. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116723 · Cited by 5 · see citing works
Qin, X., Ma, X., Tu, D., Luo, Z., Huang, J., & Mo, C. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.11.004 · Cited by 5 · see citing works
Oxytocin Release: A Remedy for Cerebral Inflammaging
Buemann, B. (2022) · Current Aging Science · doi:10.2174/1874609815666220414104832 · Cited by 4 · see citing works
Wu, R., Xu, Z., Song, Z., & Tai, F. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105366 · Cited by 4 · see citing works
Qin, X., Ma, X., Liang, J., Tu, D., Luo, Z., Huang, J., & Mo, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.047 · Cited by 4 · see citing works
Treatment of Delayed Ejaculation
Piche, K., Mann, U., & Patel, P. (2020) · Current Sexual Health Reports · doi:10.1007/s11930-020-00287-z · Cited by 3 · see citing works
Wu, C., Cheng, M., Zhang, J., Ji, X. S., Chen, P., & Yu, P. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115057 · Cited by 2 · see citing works
Modelos experimentais para o estudo do transtorno obsessivo compulsivo: perspectivas e limitações
Raminelli, A. O. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2021.tde-10052021-142439 · Cited by 2 · see citing works
Rol Modulador de la Oxitocina en la Interacción Social y el Estrés Social
Flórez-Acevedo, S., & Cárdenas, F. P. (2017) · Universitas Psychologica · doi:10.11144/javeriana.upsy15-5.rmoi · Cited by 1 · see citing works
Cross-talk between the Oxytocin and Vasopressin Systems in the Brian: Roles in Social Behavior
Song, Z. (2022) · Digital Archive @ GSU · doi:10.57709/7996120
Sukharev, A., Alade, T., Shah, V. S., & Dahmani, S. (2024) · Georgetown Medical Review · doi:10.52504/001c.117947
Avaliação temporal dos efeitos da hipertensão renovascular sobre a função reprodutiva de ratos
Weissheimer, K. V. (2011) · Americanae (AECID Library)
- Authors
- Gil, M., Bhatt, R., Picotte, K. B., & Hull, E. M.
- Affiliations
- Florida State University (US)
- Corresponding author
- Gil, Mario
- ORCID
- Hull, Elaine M.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 59
- Issue
- 4
- Pages
- 435-443
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3081415
- OpenAlex
- W2159591827
- Cited by
- 70
- References
- 105
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 1
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH040826, MH040826)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, medial preoptic area, male sexual behavior, copulation, arginine vasotocin
- MeSH terms
- Analysis of Variance, Animals, Autoradiography, Copulation, Ejaculation, Male, Microinjections, Motor Activity, Oxytocin, Preoptic Area, Receptors, Oxytocin, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
