Cited by 169Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorHypothalamic control of reproductive hormones

Sexual behavior increases c-fos expression in the forebrain of the male rat

Robertson, G.S., Pfaus, J.G., Atkinson, L.J., Matsumura, H., Phillips, A.G., Fibiger, H.C.·1991·Brain Research

Abstract

The ability of a wide variety of pharmacological and physiological stimuli to increase neuronal expression of Fos has led to the suggestion that it might serve as a marker of neuronal activation. Psychomotor stimulants increase the release of dopamine from the terminals of nigrostriatal and mesolimbic neurons and enhance Fos immunoreactivity in the striatum and nucleus accumbens (NAc). Because sexual behavior also increases dopamine release in these and other forebrain regions, the present study examined the effect of copulation on Fos immunoreactivity in the forebrain of intact, sexually active male rats. Sexual behavior produced a striking increase in Fos immunoreactivity in the medial preoptic area (MPOA), NAc, bed nucleus of the stria terminalis and piriform cortex. However, no increase in Fos immunoreactivity was observed in the striatum. These results are consistent with neurochemical, physiological, and behavioral data suggesting that the MPOA and NAc are important substrates of sexual behavior.

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Crossref · 10.1016/0006-8993(91)91477-i

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Authors
Robertson, G. S., Pfaus, J. G., Atkinson, L. J., Matsumura, H., Phillips, A. G., & Fibiger, H. C.
Affiliations
  • University of British Columbia (CA)
  • Rockefeller University (US)
Corresponding author
Fibiger, H.C.
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-11
Volume
564
Issue
2
Pages
352-357
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2118594719
Cited by
169
References
42
Citations by year
2025: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 4
FWCI
3.67
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32ns008621-02)
  • National Institute of Neurological Disorders and Stroke (NS08621)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
sexual behavior, copulation, Fos expression, Fos-like immunoreactivity, neuronal activation, medial preoptic area, nucleus accumbens, bed nucleus of the stria terminalis, piriform cortex, forebrain, dopamine release, striatum, male rats
MeSH terms
Animals, Brain Chemistry, Corpus Striatum, Female, Male, Nucleus Accumbens, Ovariectomy, Preoptic Area, Rats, Inbred Strains, Sexual Behavior, Animal, Proto-Oncogene Proteins c-fos, Rats

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