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Cholinergic antagonists and REM sleep generation
Abstract
In this study we extended our observations on the role of M1 and M2 muscarinic receptors in mediating the cholinergic induction of REM sleep. Cats were chronically implanted with sleep recording electrodes and microinjections of Ringer's or muscarinic antagonists followed by the relatively specific M2 muscarinic agonist, cis-methyl-dioxolane (cisdioxo), were made into the medial pontine reticular formation (mPRF). The microinjection of Ringer's followed by cisdioxo significantly increased REM sleep percentage. Atropine, a mixed muscarinic receptor antagonist, administered before cisdioxo blocked the REM sleep increase while pirenzepine, a selective M1 muscarinic antagonist, did not block the cisdioxo-induced increase in REM sleep. Gallamine, a nicotinic and a putative M2 antagonist, tended to inhibit the cisdioxo-induced increase in REM sleep. These results support the hypothesis that the cholinergic stimulation-induced REM sleep in the medial pontine reticular formation is mediated by a non-M1 muscarinic receptor subtype.
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Cholinergic systems exert significant effects on the initiation of a REM interval, while norepinephrine and serotonin play important roles in terminating a REM period.
“Cholinergic systems exert significant effects on the initiation of a REM interval, while the monoamine neurotransmitters norepinephrine (NE) and serotonin (5-HT) play important roles in terminating a REM period [McCarley and Hobson, 1975;Velazquez-Moctezuma et al., 1991].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Velazquez-Moctezuma et al., 1991
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Cites
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Hobson, J. A., Pace-Schott, E. F., & Stickgold, R. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00003976 · Cited by 985
The reinterpretation of dreams: An evolutionary hypothesis of the function of dreaming
Revonsuo, A. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00004015 · Cited by 676
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Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Baird, B., Castelnovo, A., Riedner, B. A., Lutz, A., Ferrarelli, F., Boly, M., Davidson, R. J., & Tononi, G. (2018) · eneuro · doi:10.1523/eneuro.0293-18.2018 · Cited by 45
“…(EEG) slow waves, and widespread bistability of cortical membrane potentials (Steriade et al., 2001), during REM sleep the cortex resumes wake-like global activity levels, primarily caused by neuronal activation through brainstem cholinergic projections (Velazquez-Moctezuma et al., 1991).”
Background
Metadata
- Authors
- Velazquez-Moctezuma, J., Shalauta, M., Christian Gillin, J., & Shiromani, P. J.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Shiromani, Priyattam J.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 543
- Issue
- 1
- Pages
- 175-179
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2083235604
- Cited by
- 63
- References
- 1
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH038738, NIMH-38738)
- National Institute of Neurological Disorders and Stroke (R29NS025212)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- REM sleep, muscarinic receptors, M1 muscarinic receptor, M2 muscarinic receptor, atropine, pirenzepine, gallamine, nicotinic acetylcholine receptors, cats
- MeSH terms
- Animals, Atropine, Brain, Dioxolanes, Electroencephalography, Electromyography, Electrooculography, Gallamine Triethiodide, Male, Pirenzepine, Receptors, Muscarinic, Reticular Formation, Sleep, REM, Rats
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