The DOI matches its Crossref record; 18 of the 20 references it cites were found in a registry or an index.
A two-trial memory task with automated recording: study in young and aged rats
Abstract
A two-trial recognition task, based on place or object exploration in a Y-maze, was developed to study memory in adult and aged rats. This paradigm avoids the use of electric shocks or deprivation that may have non-specific influences on the responses, and the task does not require learning of a rule. A number of behavioral parameters in several animals could be recorded automatically. These behavioral parameters were found to be differently influenced both by the type of recognition (place vs. object) and by the inter-trial interval (recognition retention time). Impaired recognition was also detected in 18-months-old rats. This recognition task which combines simplicity, sensitivity and high specificity may thus be a useful adjunct to our current battery of memory tasks.
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“The two-trial Y-maze delayed alternation task is a specific and sensitive test of spatial recognition memory in rodents (47, 48).”
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Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 803
Vallée, M., Mayo, W., Dellu-Hagedorn, F., Moal, M. L., Simon, H., & Maccari, S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02626.1997 · Cited by 787
Self-citationHippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676
Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657
Metadata
- Authors
- Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H.
- Affiliations
- Université de Bordeaux (FR)
- Corresponding author
- Simon, H.
- ORCID
- Mayo, W.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 588
- Issue
- 1
- Pages
- 132-139
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1984139645
- Cited by
- 390
- References
- 20
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 13 · 2023: 17 · 2022: 16 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 24 · 2013: 22 · 2012: 12
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- recognition memory, Y-maze, place recognition, object recognition, aging, aged rats, memory impairment, intertrial interval
- MeSH terms
- Aging, Animals, Discrimination, Psychological, Exploratory Behavior, Male, Memory, Rats, Sprague-Dawley, Rats
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