A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data

Ennaceur, A.; Delacour, J.

doi:10.1016/0166-4328(88)90157-x

Cited by 3,223Memory and Neural MechanismsMemory Processes and InfluencesCognitive Abilities and Testing

A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data

Ennaceur, A., Delacour, J.·1988·Behavioural Brain Research

DOI 10.1016/0166-4328(88)90157-x

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Abstract

In this paper we describe a new memory test in rats, based on the differential exploration of familiar and new objects. In a first trial (T1), rats are exposed to one or to two identical objects (samples) and in a second trial, to two dissimilar objects, a familiar (the sample) and a new one. For short intertrial intervals (approximately 1 min), most rats discriminate between the two objects in T2: they spend more time in exploring the new object than the familiar one. This test has several interesting characteristics: (1) it is similar to visual recognition tests widely used in subhuman primates, this allows interspecies comparisons; (2) it is entirely based on the spontaneous behavior of rats and can be considered as a 'pure' working-memory test completely free of reference memory component; (3) it does not involve primary reinforcement such as food or electric shocks, this makes it comparable to memory tests currently used in man.

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Rodents can retain object information for at least 24 hours after exposure.
“Studies have reported that rodents can retain object information for at least 24 hours after the exposure (Ennaceur and Delacour, 1988).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ennaceur and Delacour, 1988
The difference between the duration of exploration of a novel versus familiar object can be taken as an indication for memory, by the argument that animals tend to explore novel objects more because they remember the familiar ones.
“The difference between the duration of exploration of a novel versus familiar object can be taken as an indication for memory, by the argument that animals tend to explore novel objects more because they remember the familiar ones (Ennaceur and Delacour, 1988).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ennaceur and Delacour, 1988
NOP performance is variably dependent upon the time interval between the learning and test trials.
“NOP performance is variably dependent upon the time interval between the learning and test trials (Ennaceur and Delacour, 1988).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ennaceur and Delacour, 1988

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A new one-trial test for neurobiological studies of memory in rats
Ennaceur, A., & Lacour, J. D. (1988)
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New methods for testing visual recognition memory in the rat
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A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory
Ennaceur, A., & Meliani, K. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80315-8 · Cited by 276 · see citing works
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Authors: Ennaceur, A., & Delacour, J.
Affiliations: Université Paris Diderot (FR)
Corresponding author: Ennaceur, A.
ORCID: Ennaceur, A.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 1988-11
Volume: 31
Issue: 1
Pages: 47-59
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/0166-4328(88)90157-x
OpenAlex: W2072441360
Cited by: 3,223
References: 46
Citations by year: 2026: 105 · 2025: 124 · 2024: 148 · 2023: 138 · 2022: 143 · 2021: 179 · 2020: 172 · 2019: 189 · 2018: 171 · 2017: 182 · 2016: 166 · 2015: 161 · 2014: 161 · 2013: 134 · 2012: 152
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Sunderland Repository (University of Sunderland) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords: object recognition memory, rats, working memory, reference memory, visual recognition memory, cross-species comparison, spontaneous behavior
MeSH terms: Animals, Attention, Brain, Exploratory Behavior, Habituation, Psychophysiologic, Male, Memory, Orientation, Rats, Inbred Strains, Mental Recall, Retention, Psychology, Rats

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A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data

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