Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Open accessAbstract
Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The OPP test has been shown to be hippocampus-dependent in rodents.
“The OPP test has been shown to be hippocampus-dependent in rodents (Barker and Warburton, 2011b; Mumby et al., 2002).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Mumby et al., 2002
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924 · see citing works
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Aggleton, J. P., & Brown, M. W. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002034 · Cited by 1,879 · see citing works
A cortical–hippocampal system for declarative memory
Eichenbaum, H. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036213 · Cited by 1,725 · see citing works
Two functional components of the hippocampal memory system
Eichenbaum, H., Otto, T., & Cohen, N. J. (1994) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00035391 · Cited by 1,094 · see citing works
The hippocampus and contextual retrieval of information from memory: A theory
Hirsh, R. (1974) · Behavioral Biology · doi:10.1016/s0091-6773(74)92231-7 · Cited by 957 · see citing works
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740 · see citing works
Design and analysis: A researcher's handbook, 3rd ed.
Keppel, G. (1991) · Cited by 705 · see citing works
Ennaceur, A., Neave, N., & Aggleton, J. P. (1997) · Experimental Brain Research · doi:10.1007/pl00005603 · Cited by 670 · see citing works
Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.1093 · Cited by 615 · see citing works
Dix, S. L., & Aggleton, J. P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00079-5 · Cited by 598 · see citing works
Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat.
Sutherland, R., Kolb, B., & Whishaw, I. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90032-5 · Cited by 573 · see citing works
The effects of hippocampal lesions upon spatial and non-spatial tests of working memory
Aggleton, J. P., Hunt, P. R., & Rawlins, J. N. P. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90011-2 · Cited by 496 · see citing works
A two-trial memory task with automated recording: study in young and aged rats
Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91352-f · Cited by 390 · see citing works
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
Ennaceur, A., Neave, N., & Aggleton, J. P. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00006-x · Cited by 351 · see citing works
Kesner, R., Bolland, B. L., & Dakis, M. (1993) · Experimental Brain Research · doi:10.1007/bf00229361 · Cited by 325 · see citing works
Maren, S., & Fanselow, M. S. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3752 · Cited by 324 · see citing works
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.19 · Cited by 240 · see citing works
Mumby, D. G., Wood, E. R., & Pinel, J. P. J. (1992) · Psychobiology · doi:10.3758/bf03327156 · Cited by 219 · see citing works
Baxter, M. G., & Murray, E. A. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 186 · see citing works
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.19 · Cited by 184 · see citing works
The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats
Shaw, C., & Aggleton, J. P. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90051-q · Cited by 181 · see citing works
Object recognition memory in the rat: the role of the hippocampus
Rothblat, L. A., & Kromer, L. F. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80036-1 · Cited by 167 · see citing works
Hippocampal lesions and path integration
Whishaw, I. Q., McKenna, J. E., & Maaswinkel, H. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80011-6 · Cited by 163 · see citing works
Rawlins, J. N. P., Lyford, G. L., Seferiades, A., Deacon, R. M. J., & al, E. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.3.420 · Cited by 158 · see citing works
Rats with lesions of the hippocampus are impaired on the delayed nonmatching‐to‐sample task†
Clark, R. E., West, A. N., Zola, S. M., & Squire, L. R. (2001) · Hippocampus · doi:10.1002/hipo.1035 · Cited by 135 · see citing works
Warburton, E. C., & Aggleton, J. P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00047-3 · Cited by 127 · see citing works
Rawlins, J. N. P., Lyford, G. L., Seferiades, A., et al. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.3.420 · Cited by 123 · see citing works
Spontaneous recognition of object configurations in rats: effects of fornix lesions
Ennaceur, A., & Aggleton, J. P. (1994) · Experimental Brain Research · doi:10.1007/bf00227281 · Cited by 121 · see citing works
Duva, C. A., Floresco, S., Wunderlich, G. R., Lao, T. L., Pinel, J. P. J., & Phillips, A. G. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.6.1184 · Cited by 111 · see citing works
Recognition memory in rats—II. Neuroanatomical substrates
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A., & Aggleton, J. P. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00061-0 · Cited by 108 · see citing works
Save, É., Buhot, M.-C., Foreman, N., & Thinus‐Blanc, C. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80118-4 · Cited by 106 · see citing works
Duva, C. A., Floresco, S., Wunderlich, G. R., et al. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.6.1184 · Cited by 96 · see citing works
Mumby, D. G., Wood, E. R., Duva, C. A., Kornecook, T. J., Pinel, J. P. J., & Phillips, A. G. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.266 · Cited by 94 · see citing works
Continuous recognition of spatial and nonspatial stimuli in hippocampal-lesioned rats
Jackson-Smith, P. A., Kesner, R. P., & Chiba, A. A. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90821-x · Cited by 94 · see citing works
Wiig, K. A., & Bilkey, D. K. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.4.620 · Cited by 91 · see citing works
Yee, B., & Rawlins, J. N. P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03766.1994 · Cited by 89 · see citing works
The hippocampus, objects, and their contexts.
Cassaday, H. J., & Rawlins, J. N. P. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.6.1228 · Cited by 83 · see citing works
Mumby, D. G., Wood, E. R., Duva, C. A., et al. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.266 · Cited by 71 · see citing works
Self-citationWiig, K. A., & Bilkey, D. K. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.620 · Cited by 71 · see citing works
Mumby, D. G., Pinel, J. P. J., Kornecook, T. J., Shen, M. J., & Redila, V. A. (1995) · Psychobiology · doi:10.3758/bf03327055 · Cited by 67 · see citing works
Animal models of medial temporal lobe amnesia: The myth of the hippocampus.
Duva, C. A., Kornecook, T. J., & Pinel, J. P. J. (2004) · American Psychological Association eBooks · doi:10.1037/10335-012 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448 · see citing works
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464 · see citing works
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985 · see citing works
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909 · see citing works
“An exploration ratio was calculated (exploration ratio = freq. smell #3/(freq. smell #3 + freq. smell #2B)×100).”
MethodWhen Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676 · see citing works
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.005 · Cited by 669 · see citing works
Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58642 · Cited by 619 · see citing works
Assessing rodent hippocampal involvement in the novel object recognition task. A review
Cohen, S. J., & Stackman, R. W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.002 · Cited by 595 · see citing works
Fuchs, E. C., Zivkovic, A. R., Cunningham, M. O., Middleton, S., LeBeau, F. E. N., Bannerman, D. M., Rozov, A., Whittington, M. A., Traub, R. D., Rawlins, J. N. P., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.031 · Cited by 532 · see citing works
Recognition memory and the human hippocampus.
Manns, J., Hopkins, R., Reed, J. M., Kitchener, E. G., & Squire, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01147-9 · Cited by 472 · see citing works
On the delay-dependent involvement of the hippocampus in object recognition memory
HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works
Recollection-like memory retrieval in rats is dependent on the hippocampus
Fortin, N. J., Wright, S. P., & Eichenbaum, H. (2004) · Nature · doi:10.1038/nature02853 · Cited by 460 · see citing works
Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex
Deshmukh, S. S., & Knierim, J. J. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00069 · Cited by 454 · see citing works
Examining Object Location and Object Recognition Memory in Mice
Ciernia, A. V., & Wood, M. A. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0831s69 · Cited by 426 · see citing works
Glucocorticoid effects on object recognition memory require training-associated emotional arousal
Okuda, S., Roozendaal, B., & McGaugh, J. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307803100 · Cited by 402 · see citing works
Majumder, S., Richardson, A. G., Strong, R., & Oddo, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025416 · Cited by 401 · see citing works
Modulation of long-term memory for object recognition via HDAC inhibition
Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K., & Wood, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903964106 · Cited by 402 · see citing works
The hippocampal indexing theory and episodic memory: Updating the index
Teyler, T. J., & Rudy, J. W. (2007) · Hippocampus · doi:10.1002/hipo.20350 · Cited by 373 · see citing works
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?
Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 371 · see citing works
Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362 · see citing works
Rapid enhancement of visual and place memory by estrogens in rats.
Luine, V., Jacome, L. F., & MacLusky, N. (2003) · Endocrinology · doi:10.1210/en.2003-0004 · Cited by 375 · see citing works
Integrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
The rodent hippocampus is essential for nonspatial object memory
Cohen, S. J., Munchow, A. H., Rios, L. M., Zhang, G., Ásgeirsdóttir, H. N., & Stackman, R. W. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.002 · Cited by 325 · see citing works
Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy
Christie, L.-A., Acharya, M. M., Parihar, V. K., Nguyen, A., Martirosian, V., & Limoli, C. L. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2000 · Cited by 311 · see citing works
Neural circuitry for rat recognition memory
Warburton, E. C., & Brown, M. W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.050 · Cited by 307 · see citing works
Behavioural study of the -galactose induced aging model in C57BL/6J mice
WEI, H., LI, L., SONG, Q., Hou-xi, A., CHU, J., & Li, W. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.07.003 · Cited by 304 · see citing works
Behavioral tagging is a general mechanism of long-term memory formation
Ballarini, F., Moncada, D., Martinez, M. C., Alen, N., & Viola, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907078106 · Cited by 301 · see citing works
Rosa, R. D., Garcia, A. A., Braschi, C., Capsoni, S., Maffei, L., Berardi, N., & Cattaneo, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500195102 · Cited by 302 · see citing works
Young, J., Powell, S., Risbrough, V., Marston, H., & Geyer, M. (2009) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2009.02.004 · Cited by 315 · see citing works
Context representations, context functions, and the parahippocampal–hippocampal system
Rudy, J. W. (2009) · Learning & Memory · doi:10.1101/lm.1494409 · Cited by 296 · see citing works
Bélarbi, K., Jopson, T. D., Tweedie, D., Arellano, C., Luo, W., Greig, N. H., & Rosi, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-23 · Cited by 285 · see citing works
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
Migues, P. V., Hardt, O., Wu, D. C., Gamache, K., Sacktor, T. C., Wang, Y. T., & Nader, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2531 · Cited by 283 · see citing works
Rossato, J. I., Bevilaqua, L. R. M., Myskiw, J. C., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Learning & Memory · doi:10.1101/lm.422607 · Cited by 282 · see citing works
Small Conductance Ca2+-Activated K+Channels Modulate Synaptic Plasticity and Memory Encoding
Stackman, R. W., Hammond, R., Linardatos, E., Gerlach, A. C., Maylie, J., Adelman, J. P., & Tzounopoulos, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10163.2002 · Cited by 275 · see citing works
The neurobiology of memory changes in normal aging
Erickson, C. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00160-2 · Cited by 267 · see citing works
Sleep for Preserving and Transforming Episodic Memory
Inostroza, M., & Jan Born, A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170429 · Cited by 265 · see citing works
Aungst, S. L., Kabadi, S. V., Thompson, S. M., Stoica, B. A., & Faden, A. I. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.75 · Cited by 254 · see citing works
Wistar rats show episodic-like memory for unique experiences
KARTTEKE, E., DESOUZASILVA, M., HUSTON, J., & DERE, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.10.002 · Cited by 250 · see citing works
Langston, R. F., & Wood, E. R. (2009) · Hippocampus · doi:10.1002/hipo.20714 · Cited by 244 · see citing works
Integrated memory for objects, places, and temporal order: Evidence for episodic-like memory in mice
Dere, E., Huston, J. P., & De Souza Silva, M. A. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.07.002 · Cited by 243 · see citing works
Barrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243 · see citing works
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.08.001 · Cited by 242 · see citing works
MacLusky, N., Luine, V., Hajszán, T., & Léránth, C. (2005) · Endocrinology · doi:10.1210/en.2004-0730 · Cited by 228 · see citing works
Barrett, R. M., & Wood, M. A. (2008) · Learning & Memory · doi:10.1101/lm.917508 · Cited by 239 · see citing works
A cognitive map for object memory in the hippocampusPreprint
Manns, J. R., & Eichenbaum, H. (2009) · Learning & Memory · doi:10.1101/lm.1484509 · Cited by 240 · see citing works
Southwell, A. L., Ko, J., & Patterson, P. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4286-09.2009 · Cited by 233 · see citing works
Lateral entorhinal cortex is critical for novel object‐context recognition
Wilson, D. I. G., Langston, R. F., Schlesiger, M. I., Wagner, M. A., Watanabe, S., & Ainge, J. A. (2013) · Hippocampus · doi:10.1002/hipo.22095 · Cited by 232 · see citing works
A neural-level model of spatial memory and imagery
Bicanski, A., & Burgess, N. (2018) · eLife · doi:10.7554/elife.33752 · Cited by 230 · see citing works
Lutz, S. E., Zhao, Y., Gulinello, M. E., Lee, S. C., Raine, C. S., & Brosnan, C. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0341-09.2009 · Cited by 228 · see citing works
Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
Oliveira, A. M. M., Hawk, J. D., Abel, T., & Havekes, R. (2010) · Learning & Memory · doi:10.1101/lm.1625310 · Cited by 222 · see citing works
Update on Memory Systems and Processes
Nadel, L., & Hardt, O. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.169 · Cited by 216 · see citing works
Norman, G., & Eacott, M. J. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.557 · Cited by 217 · see citing works
Exercise improves cognition and hippocampal plasticity in <i>APOE</i> ɛ4 mice
Nichol, K., Deeny, S. P., Seif, J., Camaclang, K., & Cotman, C. W. (2009) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.02.006 · Cited by 213 · see citing works
Balderas, I., Rodriguez-Ortiz, C. J., Salgado-Tonda, P., Chavez-Hurtado, J., McGaugh, J. L., & Bermudez-Rattoni, F. (2008) · Learning & Memory · doi:10.1101/lm.1028008 · Cited by 213 · see citing works
Eichenbaum, H., & Lipton, P. A. (2008) · Hippocampus · doi:10.1002/hipo.20500 · Cited by 213 · see citing works
Ager, R. R., Davis, J. L., Agazaryan, A., Benavente, F., Poon, W. W., LaFerla, F. M., & Blurton-Jones, M. M. (2014) · Hippocampus · doi:10.1002/hipo.22405 · Cited by 212 · see citing works
Pascoe, M. C., Howells, D. W., Crewther, D. P., Constantinou, N., Carey, L. M., Rewell, S. S. J., Turchini, G. M., Kaur, G., & Crewther, S. G. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00014 · Cited by 211 · see citing works
Haettig, J., Stefanko, D. P., Multani, M. L., Figueroa, D. X., McQuown, S. C., & Wood, M. A. (2011) · Learning & Memory · doi:10.1101/lm.1986911 · Cited by 211 · see citing works
Object recognition testing: Methodological considerations on exploration and discrimination measures
Akkerman, S., Blokland, A., Reneerkens, O. A. H., van Goethem, N. P., Bollen, E., Gijselaers, H. J. M., Lieben, C. K. J., Steinbusch, H. W. M., & Prickaerts, J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.022 · Cited by 208 · see citing works
Hales, J. B., Schlesiger, M. I., Leutgeb, J. K., Squire, L. R., Leutgeb, S., & Clark, R. E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.009 · Cited by 204 · see citing works
The case for episodic memory in animals
Dere, E., KARTTEKE, E., Huston, J. P., & DESOUZASILVA, M. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.005 · Cited by 202 · see citing works
Distinct roles of medial and lateral entorhinal cortex in spatial cognition
Van Cauter, T., Camon, J., Alvernhe, A., Elduayen, C., Sargolini, F., & Save, E. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs033 · Cited by 196 · see citing works
Revisiting the open-field test: what does it really tell us about animal personality?
Perals, D., Griffin, A. S., Bartomeus, Í., & Sol, D. (2016) · Animal Behaviour · doi:10.1016/j.anbehav.2016.10.006 · Cited by 197 · see citing works
Sui, L., Wang, J., & Li, B.-M. (2008) · Learning & Memory · doi:10.1101/lm.1067808 · Cited by 195 · see citing works
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
Labrie, V., Fukumura, R., Rastogi, A., Fick, L. J., Wang, W., Boutros, P. C., Kennedy, J. L., Semeralul, M. O., Lee, F. H., Baker, G. B., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp261 · Cited by 185 · see citing works
Ontogeny of Rat Recognition Memory measured by the novel object recognition task
Reger, M. L., Hovda, D. A., & Giza, C. C. (2009) · Developmental Psychobiology · doi:10.1002/dev.20402 · Cited by 179 · see citing works
VanElzakker, M. B., Fevurly, R. D., Breindel, T., & Spencer, R. L. (2008) · Learning & Memory · doi:10.1101/lm.1196508 · Cited by 179 · see citing works
Briones, T. L., & Darwish, H. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-244 · Cited by 176 · see citing works
Sleep and memory in mammals, birds and invertebrates
Vorster, A. P., & Born, J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.020 · Cited by 169 · see citing works
Mao, P., Mańczak, M., Calkins, M. J., Truong, Q., Reddy, T. P., Reddy, A. P., Shirendeb, U. P., Lo, H., Rabinovitch, P. S., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds128 · Cited by 174 · see citing works
Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators
Hueston, C. M., Cryan, J. F., & Nolan, Y. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.48 · Cited by 171 · see citing works
Increased Fear Response to Contextual Cues in Mice Lacking the 5-HT1A Receptor
Klemenhagen, K. C., Gordon, J. A., David, D. J. P., Hen, R., & Gross, C. T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300774 · Cited by 167 · see citing works
Neotic preferences in laboratory rodents: Issues, assessment and substrates
Hughes, R. N. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.004 · Cited by 160 · see citing works
Heyward, F. D., Walton, R. G., Carle, M. S., Coleman, M. A., Garvey, W. T., & Sweatt, J. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.005 · Cited by 165 · see citing works
Inagaki, T., Gautreaux, C., & Luine, V. N. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.013 · Cited by 164 · see citing works
DeVito, L. M., & Eichenbaum, H. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.014 · Cited by 164 · see citing works
Assini, F. L., Duzzioni, M., & Takahashi, R. N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.005 · Cited by 161 · see citing works
Retrograde and anterograde object recognition in rats with hippocampal lesions
Gaskin, S., Tremblay, A., & Mumby, D. G. (2003) · Hippocampus · doi:10.1002/hipo.10154 · Cited by 160 · see citing works
The role of hippocampal subregions in memory for stimulus associations
Langston, R. F., Stevenson, C. H., Wilson, C. L., Saunders, I., & Wood, E. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.006 · Cited by 161 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Sex Steroids and Cognitive Function
Luine, V. N. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01710.x · Cited by 159 · see citing works
Neural Stem Cells Improve Memory in an Inducible Mouse Model of Neuronal Loss
Yamasaki, T. R., Blurton-Jones, M. M., Morrissette, D. A., Kitazawa, M., Oddo, S., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1627-07.2007 · Cited by 158 · see citing works
Phosphodiesterase type 5 inhibition improves early memory consolidation of object information
Prickaerts, J., Şık, A., van Staveren, W. C. G., Koopmans, G. C., Steinbusch, H. W. M., van der Staay, F. J., de Vente, J., & Blokland, A. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.022 · Cited by 156 · see citing works
Migues, P. V., Liu, L., Archbold, G. E. B., Einarsson, E. Ö., Wong, J., Bonasia, K., Ko, S. H., Wang, Y. T., & Hardt, O. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3333-15.2016 · Cited by 153 · see citing works
Bachevalier, J., & Nemanic, S. (2007) · Hippocampus · doi:10.1002/hipo.20369 · Cited by 149 · see citing works
Malin, E. L., & McGaugh, J. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510890103 · Cited by 147 · see citing works
Myelin as a regulator of development of the microbiota-gut-brain axis
Keogh, C. E., Kim, D. H. J., Pusceddu, M. M., Knotts, T. A., Rabasa, G., Sladek, J. A., Hsieh, M. T., Honeycutt, M., Brust-Mascher, I., Barboza, M., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.001 · Cited by 137 · see citing works
Rohn, T. T., Vyas, V., Hernandez-Estrada, T., Nichol, K. E., Christie, L.-A., & Head, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5620-07.2008 · Cited by 146 · see citing works
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.021 · Cited by 142 · see citing works
Jenrow, K. A., Brown, S. L., Lapanowski, K., Naei, H., Kolozsvary, A. J. J., & Kim, J. H. (2013) · Radiation Research · doi:10.1667/rr3026.1 · Cited by 141 · see citing works
Meeter, M., Murre, J. M. J., & Talamini, L. M. (2004) · Hippocampus · doi:10.1002/hipo.10214 · Cited by 138 · see citing works
Krukowski, K., Chou, A., Feng, X., Tiret, B., Paladini, M. S., Riparip, L., Chaumeil, M. M., Lemere, C. A., & Rosi, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123753 · Cited by 139 · see citing works
Labrie, V., Lipina, T. V., & Roder, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1196-6 · Cited by 141 · see citing works
Ainge, J. A., Heron-Maxwell, C., Theofilas, P., Wright, P., de Hoz, L., & Wood, E. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.09.005 · Cited by 140 · see citing works
Recognition memory: Material, processes, and substrates
Brown, M. W., Warburton, E. C., & Aggleton, J. P. (2010) · Hippocampus · doi:10.1002/hipo.20858 · Cited by 138 · see citing works
Young hippocampal neurons are critical for recent and remote spatial memory in adult mice
Goodman, T. H., Trouche, S. G., Massou, I., Verret, L., Zerwas, M., Roullet, P., & Rampon, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.047 · Cited by 136 · see citing works
Czerniawski, J. L., Miyashita, T., Lewandowski, G. A., & Guzowski, J. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.014 · Cited by 137 · see citing works
Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory
Wilson, D. I. G., Watanabe, S., Milner, H., & Ainge, J. A. (2013) · Hippocampus · doi:10.1002/hipo.22165 · Cited by 137 · see citing works
- Authors
- Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H.
- Affiliations
- Concordia University (CA)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-01
- Volume
- 9
- Issue
- 2
- Pages
- 49-57
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC155935
- OpenAlex
- W2024032885
- Cited by
- 714
- References
- 44
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 19 · 2023: 24 · 2022: 28 · 2021: 26 · 2020: 36 · 2019: 34 · 2018: 37 · 2017: 28 · 2016: 36 · 2015: 30 · 2014: 49 · 2013: 43 · 2012: 55
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- hippocampal lesions, novelty preference, object recognition memory, place memory, contextual memory, spatial memory, hippocampal formation, rats, cytotoxic lesions, memory impairment
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Exploratory Behavior, Hippocampus, Male, Memory, Pattern Recognition, Visual, Space Perception, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review