The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Reserpine impairs spatial working memory performance in monkeys: reversal by the α2-adrenergic agonist clonidine
Abstract
Repeated daily treatment with the catecholamine-depleting agent, reserpine, dramatically reduced performance on the delayed response task, a test of spatial working memory that depends upon the integrity of the prefrontal cortex. Delayed response performance fell from an average of 27.2/30 trials correct before reserpine treatment to an average of 20.4/30 trials correct after repeated reserpine administration. Injection of the alpha 2-adrenergic agonist, clonidine (0.0001-0.05 mg/kg), to chronic reserpine-treated monkeys significantly restored performance on the delayed response task; performance after an optimal dose averaged 27.8/30 trials correct. Clonidine's beneficial effects on delayed response performance were longlasting; monkeys remained improved for more than 24 h after a single clonidine injection. The finding that clonidine is efficacious in reserpinized animals supports the hypothesis that alpha 2-adrenergic agonists improve cognitive function through actions at postsynaptic, alpha 2-adrenergic receptors on non-adrenergic cells. In contrast to the delayed response task, reserpine had little effect on performance of a visual discrimination task, a reference memory task which does not depend on the prefrontal cortex. These results emphasize the importance of postsynaptic, alpha 2-adrenergic mechanisms in the regulation of working memory.
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“Although previous research focused on presynaptic receptor actions, research has established that the beneficial effects of α2-agonists arise from stimulation of postsynaptic α2A-receptors in the PFC (Arnsten and Goldman-Rakic, 1985; Cai et al., 1993).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Cai et al., 1993
In the citing paper
“Thus, either depletion of noradrenaline52 or blockade of α2A-receptors in the PFC53 impairs working memory, whereas stimulation of postsynaptic α2A-receptors in the PFC improves working memory performance52,56–58.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [56]
In the citing paper
“Conversely, stimulation of postsynaptic α2A receptors in dorsolateral PFC, e.g., with guanfacine infusions directly into this region, improves working memory performance (35,41–43).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [41]
In the citing paper
“In contrast, guanfacine mimics the enhancing effects of norepinephrine at postsynaptic α2A-receptors in the PFC, strengthening network connectivity.”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [41]
In the citing paper
“early research determined that the beneficial effects of α2-AR agonists on cognition arose from postsynaptic receptor actions in the PFC (Arnsten and Goldman-Rakic, 1985, Cai et al., 1993), with a pharmacological profile consistent with the α2A-AR subtype (Arnsten et al., 1988, Arnsten and Leslie, 1991), a finding later confirmed in genetically altered mice (Franowicz et al., 2002).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Cai et al., 1993
Citations
Cites
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey
Goldman, P. S., & Rosvold, H. E. (1970) · Experimental Neurology · doi:10.1016/0014-4886(70)90222-0 · Cited by 580
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1985) · Science · doi:10.1126/science.2999977 · Cited by 549
Arnsten, A., Cai, J., & Goldman-Rakic, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04287.1988 · Cited by 391
Self-citationChronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys
Schneider, J. S., & Kovelowski, C. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90069-n · Cited by 250
Boyajian, C. L., & Leslie, F. M. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00190-9 · Cited by 138
Noradrenergic Control of Thalamic Oscillation: the Role of α‐2 Receptors
Buzsáki, G., Kennedy, B., Solt, V. B., & Ziegler, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00083.x · Cited by 123
Catecholamines and Cognitive Decline in Aged Nonhuman Primates
Arnsten, A. F. T., & Goldman, P. S. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37592.x · Cited by 89
Fields, R. B., Van Kammen, D. P., Peters, J. L., Rosen, J., Van Kammen, W. B., Nugent, A., Stipetic, M., & Linnoila, M. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90024-2 · Cited by 88
Clonidine enhances delayed matching-to-sample performance by young and aged monkeys
Jackson, W. J., & Buccafusco, J. J. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90400-v · Cited by 66
Korsakoff's psychosis: Noradrenergic systems and cognitive impairment
Mair, R. G. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90011-6 · Cited by 54
Clonidine-induced sedation in rats: Evidence for mediation by postsynaptic? 2-adrenoreceptors
Spyraki, C., & Fibiger, H. C. (1982) · Journal of Neural Transmission · doi:10.1007/bf01254925 · Cited by 54
Reynoldson, J. A., Head, G. A., & Korner, P. I. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90192-4 · Cited by 33
Clonidine reverses the amnesia induced by dopamine beta hydroxylase inhibition
Freedman, L. S., Backman, M. Z., & Quartermain, D. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90132-1 · Cited by 31
Postsynaptic spinal α-adrenoceptors mediate effects of intrathecal clonidine
Connor, H. E., & Finch, L. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90015-7 · Cited by 20
Research works printed but not linked: 1
- Jacobsen, 1936, Studies of cerebral function in primates, Comp. Psychol. Monogr., 13, 1
Cited by
Sorted by citations
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948
Modafinil: a review of neurochemical actions and effects on cognition
Minzenberg, M. J., & Carter, C. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301534 · Cited by 713
Keefe, R. S. E., Silva, S. G., Perkins, D. O., & Lieberman, J. A. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033374 · Cited by 695
Metadata
- Authors
- Cai, J. X., Ma, Y.-Y., Xu, L., & Hu, X.-T.
- Affiliations
- Kunming Institute of Zoology (CN)
- Corresponding author
- Jing Xia Cai
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 614
- Issue
- 1-2
- Pages
- 191-196
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1970116189
- Cited by
- 122
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- reserpine, clonidine, spatial working memory, alpha2-adrenoceptors, prefrontal cortex, delayed response task, reference memory, visual discrimination, catecholamine depletion, cognitive enhancement, monkeys
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Blood Pressure, Clonidine, Cognition, Discrimination, Psychological, Female, Hypnotics and Sedatives, Macaca mulatta, Male, Memory, Short-Term, Synaptic Transmission, Norepinephrine, Reserpine, Reversal Learning, Space Perception
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