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Cited by 439Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.

Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6

Zalcman, Steve, Green-Johnson, Julia M., Murray, Linda, Nance, Dwight M., Dyck, Dennis, Anisman, Hymie, Greenberg, Arnold H.·1994·Brain Research
DOI 10.1016/0006-8993(94)90006-x
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Abstract

Cytokine-specific alterations of monoamine activity were evident in the hypothalamus, hippocampus and prefrontal cortex 2 h following peripheral administration of recombinant interleukin (IL)-1 beta, IL-2 and IL-6 (200 ng, i.p.) in male, BALB/c mice. IL-1 induced the broadest range of neurochemical changes, affecting central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) activity. In particular, IL-1 enhanced NE turnover in the hypothalamus and hippocampus, 5-HT turnover in the hippocampus and prefrontal cortex (owing to increased utilization and reduced content of the transmitters in these brain regions), and enhanced DA utilization in the prefrontal cortex. IL-6 increased 5-HT and DA activity in the hippocampus and prefrontal cortex in a manner similar to IL-1, but failed to affect central NE activity. Moreover, IL-2 increased hypothalamic NE turnover (reflecting a profound increase in NE utilization) and enhanced DA turnover in the prefrontal cortex, but did not influence central 5-HT activity. Hence, these cytokines differentially altered neurochemical activity in brain regions that mediate neuroimmune interactions and that are influenced by physical and psychological stressors. In addition to the neurochemical changes, plasma corticosterone concentrations were profoundly enhanced in IL-1-treated animals, but not significantly altered by IL-2 or IL-6 treatment. The IL-1-induced corticosterone elevations did not significantly correlate with alterations of hypothalamic NE activity.

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Research works printed but not linked: 3

  1. Saphier, 1993, Central nervous system effects of α-interferon, Res. Persp. Psychoneuroimmunol., IV, A
  2. Zalcman, 1993, IL-2-induced potentiation of immune, function is mediated by the sympathetic nervous system, Soc. Neurosci. Abstr., 19, 945
  3. Zalcman, 1991, Alterations of central catecholamines associated with primary and secondary immunological challenge, Soc. Neurosci. Abstr., 17, 1202

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Metadata

Authors
Zalcman, S., Green-Johnson, J. M., Murray, L., Nance, D. M., Dyck, D., Anisman, H., & Greenberg, A. H.
Affiliations
  • University of Manitoba (CA)
  • Carleton University (CA)
Corresponding author
Greenberg, Arnold H.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-04
Volume
643
Issue
1-2
Pages
40-49
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(94)90006-x
OpenAlex
W2082698695
Cited by
439
References
51
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 7 · 2014: 19 · 2013: 14 · 2012: 18
FWCI
7.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH043778, MH-43778-04A2)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
IL-1β, interleukin-2, interleukin-6, cytokines, monoamines, norepinephrine turnover, serotonin turnover, dopamine turnover, hypothalamus, hippocampus, prefrontal cortex, neuroimmune interactions, corticosterone, stress response
MeSH terms
Animals, Brain, Chromatography, High Pressure Liquid, Corticosterone, Dopamine, Hippocampus, Humans, Hydroxyindoleacetic Acid, Hypothalamus, Interleukin-1, Interleukin-2, Male, Methoxyhydroxyphenylglycol, Mice, Inbred BALB C, Norepinephrine, Recombinant Proteins, Reference Values, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines, Interleukin-6, Prefrontal Cortex, Mice

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