The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.
Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6
Abstract
Cytokine-specific alterations of monoamine activity were evident in the hypothalamus, hippocampus and prefrontal cortex 2 h following peripheral administration of recombinant interleukin (IL)-1 beta, IL-2 and IL-6 (200 ng, i.p.) in male, BALB/c mice. IL-1 induced the broadest range of neurochemical changes, affecting central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) activity. In particular, IL-1 enhanced NE turnover in the hypothalamus and hippocampus, 5-HT turnover in the hippocampus and prefrontal cortex (owing to increased utilization and reduced content of the transmitters in these brain regions), and enhanced DA utilization in the prefrontal cortex. IL-6 increased 5-HT and DA activity in the hippocampus and prefrontal cortex in a manner similar to IL-1, but failed to affect central NE activity. Moreover, IL-2 increased hypothalamic NE turnover (reflecting a profound increase in NE utilization) and enhanced DA turnover in the prefrontal cortex, but did not influence central 5-HT activity. Hence, these cytokines differentially altered neurochemical activity in brain regions that mediate neuroimmune interactions and that are influenced by physical and psychological stressors. In addition to the neurochemical changes, plasma corticosterone concentrations were profoundly enhanced in IL-1-treated animals, but not significantly altered by IL-2 or IL-6 treatment. The IL-1-induced corticosterone elevations did not significantly correlate with alterations of hypothalamic NE activity.
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“Proinflammatory cytokines significantly affect the peripheral and central 5-HT systems.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [43]
In the citing paper
“Peripheral injections of IL-1 increase NA turnover in the hypothalamus and hippocampus, 5-HT turnover in the hippocampus and prefrontal cortex, and DA turnover in the prefrontal cortex[43].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [43]
Citations
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Cited by
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
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Metadata
- Authors
- Zalcman, S., Green-Johnson, J. M., Murray, L., Nance, D. M., Dyck, D., Anisman, H., & Greenberg, A. H.
- Affiliations
- University of Manitoba (CA)
- Carleton University (CA)
- Corresponding author
- Greenberg, Arnold H.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 643
- Issue
- 1-2
- Pages
- 40-49
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2082698695
- Cited by
- 439
- References
- 51
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 7 · 2014: 19 · 2013: 14 · 2012: 18
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH043778, MH-43778-04A2)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- IL-1β, interleukin-2, interleukin-6, cytokines, monoamines, norepinephrine turnover, serotonin turnover, dopamine turnover, hypothalamus, hippocampus, prefrontal cortex, neuroimmune interactions, corticosterone, stress response
- MeSH terms
- Animals, Brain, Chromatography, High Pressure Liquid, Corticosterone, Dopamine, Hippocampus, Humans, Hydroxyindoleacetic Acid, Hypothalamus, Interleukin-1, Interleukin-2, Male, Methoxyhydroxyphenylglycol, Mice, Inbred BALB C, Norepinephrine, Recombinant Proteins, Reference Values, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines, Interleukin-6, Prefrontal Cortex, Mice
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