Cited by 439Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

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Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6

Zalcman, Steve, Green-Johnson, Julia M., Murray, Linda, Nance, Dwight M., Dyck, Dennis, Anisman, Hymie, Greenberg, Arnold H.·1994·Brain Research

DOI 10.1016/0006-8993(94)90006-x

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Abstract

Cytokine-specific alterations of monoamine activity were evident in the hypothalamus, hippocampus and prefrontal cortex 2 h following peripheral administration of recombinant interleukin (IL)-1 beta, IL-2 and IL-6 (200 ng, i.p.) in male, BALB/c mice. IL-1 induced the broadest range of neurochemical changes, affecting central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) activity. In particular, IL-1 enhanced NE turnover in the hypothalamus and hippocampus, 5-HT turnover in the hippocampus and prefrontal cortex (owing to increased utilization and reduced content of the transmitters in these brain regions), and enhanced DA utilization in the prefrontal cortex. IL-6 increased 5-HT and DA activity in the hippocampus and prefrontal cortex in a manner similar to IL-1, but failed to affect central NE activity. Moreover, IL-2 increased hypothalamic NE turnover (reflecting a profound increase in NE utilization) and enhanced DA turnover in the prefrontal cortex, but did not influence central 5-HT activity. Hence, these cytokines differentially altered neurochemical activity in brain regions that mediate neuroimmune interactions and that are influenced by physical and psychological stressors. In addition to the neurochemical changes, plasma corticosterone concentrations were profoundly enhanced in IL-1-treated animals, but not significantly altered by IL-2 or IL-6 treatment. The IL-1-induced corticosterone elevations did not significantly correlate with alterations of hypothalamic NE activity.

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Authors: Zalcman, S., Green-Johnson, J. M., Murray, L., Nance, D. M., Dyck, D., Anisman, H., & Greenberg, A. H.
Affiliations: University of Manitoba (CA)
Carleton University (CA)
Corresponding author: Greenberg, Arnold H.
ORCID: Green-Johnson, Julia M.
Murray, Linda
Venue: Brain Research
Publisher: Elsevier BV
Published: 1994-04
Volume: 643
Issue: 1-2
Pages: 40-49
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(94)90006-x
OpenAlex: W2082698695
Cited by: 439
References: 51
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 7 · 2014: 19 · 2013: 14 · 2012: 18
FWCI: 7.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH043778, MH-43778-04A2)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: IL-1β, interleukin-2, interleukin-6, cytokines, monoamines, norepinephrine turnover, serotonin turnover, dopamine turnover, hypothalamus, hippocampus, prefrontal cortex, neuroimmune interactions, corticosterone, stress response
MeSH terms: Animals, Brain, Chromatography, High Pressure Liquid, Corticosterone, Dopamine, Hippocampus, Humans, Hydroxyindoleacetic Acid, Hypothalamus, Interleukin-1, Interleukin-2, Male, Methoxyhydroxyphenylglycol, Mice, Inbred BALB C, Norepinephrine, Recombinant Proteins, Reference Values, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines, Interleukin-6, Prefrontal Cortex, Mice

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Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6

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