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Cited by 209Sleep and Wakefulness ResearchSleep and Work-Related FatigueCoffee research and impacts

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night

Landolt, Hans-Peter, Werth, Esther, Borbély, Alexander A., Dijk, Derk-Jan·1995·Brain Research
DOI 10.1016/0006-8993(95)00040-w
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Abstract

Adenosine has been implicated in the physiological regulation of sleep propensity. The adenosine-receptor-antagonist, caffeine (100 mg), administered immediately prior to a nocturnal sleep episode, has previously been shown to lower sleep propensity as indexed by a reduced sleep efficiency, a reduced EEG power density in low delta frequencies and enhanced power density in the frequency range of sleep spindles. To further investigate the role of adenosine in sleep regulation we administered 200 mg of caffeine at 07.10 h and analyzed the sleep stages and EEG power spectra during the subsequent night in nine healthy men. Caffeine levels in saliva decreased from a maximum of 17 mumol/l one hour after intake, to 3 mumol/l immediately prior to the sleep episode starting at 23.00 h. Compared to placebo, sleep efficiency and total sleep time were significantly reduced. EEG power density in nonREM sleep was suppressed in the 0.25-0.5 Hz band and enhanced in the frequency range of sleep spindles (11.25-12.0 Hz and 13.25-14.0 Hz). In REM sleep EEG power density was suppressed in the frequency range of 0.75-4.5 and 5.25-6.0 Hz. The data indicate that a saliva level of caffeine as low as 3 mumol/l directly affects sleep propensity or, alternatively, that the presence of caffeine in the central nervous system during the waking episode reduces the progressive increase of sleep propensity associated with wakefulness.

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Crossref · 10.1016/0006-8993(95)00040-w

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Research works printed but not linked: 5

  1. Benington, 1993, A1 adenosine receptor stimulation mimics changes in non-REM sleep EEG slow-wave activity produced by sleep deprivation in the rat, Sleep Res., 22, 43
  2. Kodali, 1993, A1 adenosine receptor stimulation increases EEG delta power in the rat, Sleep Res., 22, 438
  3. Radulovacki, 1993, Adenosine sleep theory, Sleep Res., 22, 485
  4. Schwertz, 1965, Effects physiologiques de la caféine et du meprobamate au course du sommeil chez l'homme, Arch. Sci. Physiol., 119, 425
  5. Werth, 1994, Effect of an early evening nap on sleep and the sleep EEG, J. Sleep Res., 3, 276

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Metadata

Authors
Landolt, H.-P., Werth, E., Borbély, A. A., & Dijk, D.-J.
Affiliations
University of Zurich (CH)
Corresponding author
Dijk, Derk-Jan
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1995-03
Volume
675
Issue
1-2
Pages
67-74
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(95)00040-w
OpenAlex
W2000445057
Cited by
209
References
34
Citations by year
2026: 7 · 2025: 9 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 13
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31.32574.91)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords
caffeine, adenosine, sleep propensity, sleep efficiency, EEG power spectra, sleep spindles, NREM sleep, REM sleep, sleep stages, adenosine receptors, sleep regulation
MeSH terms
Adult, Arousal, Caffeine, Electrocardiography, Electroencephalography, Half-Life, Heart Rate, Humans, Male, Psychomotor Performance, Saliva, Sleep, Sleep, REM, Polysomnography

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