Does a single cup of coffee at dinner alter the sleep? a controlled cross-over randomised trial in real-life conditions
Abstract
Abstract Aim: To report changes in the quality of sleep after drinking an evening cup of either caffeinated or decaffeinated coffee, in healthy subjects in everyday life. Methods: Sixty‐three healthy men and women, who considered themselves to be caffeine sensitive were included in a double‐blind, cross‐over trial, randomised to receive either caffeinated coffee containing 90 mg of caffeine, or, as control, a dose of decaffeinated coffee containing 4.5 mg caffeine, taken after dinner. The primary outcome measure was the degree of sleep disturbance, scored on a visual analogue scale, ranging from 0 (excellent sleep) to 100 (very disturbed sleep). Ancillary criteria were patients' reported estimate of sleep latency, and how often the subjects reported waking. Results: Mean age of subjects was 30.5 ± 12 years. The quality of sleep was significantly worse with caffeinated (mean 30.8 ± 22.7) than with decaffeinated coffee (mean 19.5 ± 16.9), P = 0.001. Caffeinated coffee also significantly increased the sleep latency (mean difference 17 ± 31 minutes, P < 0.001) and the frequency of waking (mean 1.3 vs 0.8 episodes in the night, P = 0.006) compared with decaffeinated coffee. Conclusions: Even a single cup of caffeinated coffee consumed before bedtime in real‐life conditions causes a deterioration in the quality of sleep in caffeine‐sensitive subjects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Three high-risk studies did not implement a washout period, with conditions administered across consecutive nights.
“and three of these studies [26,43,53] did not implement a washout period with conditions administered across consecutive nights.”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [53]
Cites
Comparative Meta-Analysis of Pharmacotherapy and Behavior Therapy for Persistent Insomnia
Smith, M. T., Perlis, M. L., Park, A., Smith, M. S., Pennington, J., Giles, D. E., & Buysse, D. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.5 · Cited by 863 · see citing works
The Effects of Coffee and Napping on Nighttime Highway Driving
Philip, P., Taillard, J., Moore, N. D., Delord, S., Valtat, C., Sagaspe, P., & Bioulac, B. H. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-11-200606060-00004 · Cited by 650 · see citing works
Coffee consumption and risk for type 2 diabetes mellitus
Salazar-Martinez, E., Willett, W. C., Ascherio, A., Manson, J. E., Leitzmann, M. F., Stampfer, M. J., & Hu, F. B. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-1-200401060-00005 · Cited by 462 · see citing works
Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28548 · Cited by 364 · see citing works
Coffee, Caffeine, and Risk of Type 2 Diabetes
van Dam, R. M., Willett, W. C., Manson, J. E., & Hu, F. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1512 · Cited by 273 · see citing works
López‐García, E., van Dam, R. M., Qi, L., & Hu, F. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.888 · Cited by 257 · see citing works
Caffeine Use as a Model of Acute and Chronic Insomnia
Bonnet, M. H., & Arand, D. L. (1992) · SLEEP · doi:10.1093/sleep/15.6.526 · Cited by 236 · see citing works
Dose-related sleep disturbances induced by coffee and caffeine
Karacan, I., Thornby, J. I., Anch, A. M., Booth, G. H., Williams, R. L., & Salis, P. J. (1976) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1976206682 · Cited by 226 · see citing works
Suppression of sleepiness in drivers: Combination of caffeine with a short nap
Reyner, L. A., & Horne, J. A. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02148.x · Cited by 211 · see citing works
Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night
Landolt, H.-P., Werth, E., Borbély, A. A., & Dijk, D.-J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00040-w · Cited by 209 · see citing works
The Relationship of Coffee Consumption with Mortality
López‐García, E., van Dam, R. M., Li, T. Y., Rodriguez-Artalejo, F., & Hu, F. B. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-12-200806170-00003 · Cited by 201 · see citing works
Caffeine Reduces Low-Frequency Delta Activity in the Human Sleep EEG
Landolt, H. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00079-f · Cited by 198 · see citing works
Effects of caffeine on alertness
Zwyghuizen‐Doorenbos, A., Roehrs, T., Lipschutz, L., Timms, V., & Roth, T. G. (1990) · Psychopharmacology · doi:10.1007/bf02245786 · Cited by 173 · see citing works
Lelo, A., Miners, J. O., Robson, R. A., & Birkett, D. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.10 · Cited by 159 · see citing works
Williams, C. J., Fargnoli, J. L., Hwang, J. J., van Dam, R. M., Blackburn, G. L., Hu, F. B., & Mantzoros, C. S. (2008) · Diabetes Care · doi:10.2337/dc07-1952 · Cited by 159 · see citing works
Belza, A., Frandsen, E., & Kondrup, J. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803351 · Cited by 149 · see citing works
Drapeau, C., Hamel-Hébert, I., Robillard, R., Selmaoui, B., Filipini, D., & Carrier, J. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00518.x · Cited by 115 · see citing works
Shirlow, M., & Mathers, C. D. (1985) · International Journal of Epidemiology · doi:10.1093/ije/14.2.239 · Cited by 111 · see citing works
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans
Wright, K. P., Badia, P., Myers, B. L., Plenzler, S. C., & Hakel, M. D. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01268-1 · Cited by 110 · see citing works
Pharmacokinetic-pharmacodynamic modeling of caffeine: tolerance to pressor effects.
Shi, J., Benowitz, N. L., Denaro, C. P., & Sheiner, L. B. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.3 · Cited by 99 · see citing works
Dusseldorp, M., & Katan, M. B. (1990) · BMJ · doi:10.1136/bmj.300.6739.1558 · Cited by 92 · see citing works
Sartorelli, D. S., Fagherazzi, G., Balkau, B., Touillaud, M. S., Boutron‐Ruault, M., de Lauzon‐Guillain, B., & Clavel‐Chapelon, F. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28741 · Cited by 79 · see citing works
Johnson, L. C., Spinweber, C. L., Gomez, S. A., & Matteson, L. T. (1990) · SLEEP · doi:10.1093/sleep/13.2.121 · Cited by 68 · see citing works
Caffeine metabolism and coffee-attributed sleep disturbances
Levy, M., & Zylber‐Katz, E. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.105 · Cited by 66 · see citing works
A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers
Paterson, L. M., Wilson, S. J., Nutt, D., Hutson, P. H., & Ivarsson, M. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0672-0 · Cited by 59 · see citing works
Pharmacokinetic and pharmacodynamic responses to caffeine in poor and normal sleepers
Tiffin, P. A., Ashton, H., Marsh, R., Kamali, F., Ashton, H., & Marsh, R. (1995) · Psychopharmacology · doi:10.1007/bf02246500 · Cited by 54 · see citing works
Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam
Ōkuma, T., Matsuoka, H., Matsue, Y., & Toyomura, K. (1982) · Psychopharmacology · doi:10.1007/bf00432545 · Cited by 44 · see citing works
“No Thanks, It Keeps Me Awake”: The Genetics of Coffee-Attributed Sleep Disturbance
Michelle Luciano, A., Zhu, G., Kirk, K. M., Gordon, S. D., Heath, A. C., Montgomery, G. W., & Martin, N. G. (2007) · SLEEP · doi:10.1093/sleep/30.10.1378 · Cited by 39 · see citing works
Is Caffeine a Factor in Subjective Insomnia of Elderly People?
Curless, R., French, J. M., James, O., & Wynne, H. (1993) · Age and Ageing · doi:10.1093/ageing/22.1.41 · Cited by 37 · see citing works
B’chir, F., Dogui, M., Fradj, R. B., Arnaud, M. J., & Saguem, S. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2006.01.006 · Cited by 35 · see citing works
Satoh, H., & Tanaka, T. (1997) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050281 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of sleep hygiene in promoting public health: a review of empirical evidence
Irish, L. A., Kline, C. E., Gunn, H. E., Buysse, D. J., & Hall, M. H. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.10.001 · Cited by 931 · see citing works
The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 315 · see citing works
“Twelve studies reported measures of subjective sleep quality, with eight [25,26,31,33,35,36,53,54] identifying a signi fi - cant reduction in perceived sleep quality in the caffeine condition compared to the control condition and four [27,37,40,52] reporting no difference in perceived sleep quality…”
BackgroundMethodFaris, M. E., Jahrami, H., Al‐Hilali, M. M., Chehyber, N. J., Ali, S. O., Shahda, S. D., & Obaid, R. S. (2016) · Nutrition & Dietetics · doi:10.1111/1747-0080.12289 · Cited by 54 · see citing works
Liu, X., Chen, J., Zhou, J., Liu, J., Lertpitakpong, C., Tan, A., Wu, S., & Mao, Z. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244905 · Cited by 29 · see citing works
Kerpershoek, M. L., Antypa, N., & van den Berg, J. F. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12670 · Cited by 29 · see citing works
Nutra-ergonomics: influence of nutrition on physical employment standards and the health of workers
Shearer, J., Graham, T. E., & Skinner, T. L. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0531 · Cited by 24 · see citing works
Trapp, G., Hurworth, M., Jacoby, P. A., Maddison, K. J., Allen, K. L., Martin, K., Christian, H. E., Ambrosini, G. L., Oddy, W. H., & Eastwood, P. R. (2020) · Public Health Nutrition · doi:10.1017/s1368980020001652 · Cited by 23 · see citing works
Silva, H., Del Coso, J., & Pickering, C. (2025) · Sports Medicine · doi:10.1007/s40279-025-02245-y · Cited by 21 · see citing works
Hu, Y., Stephenson, K., & Klare, D. L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.12996 · Cited by 11 · see citing works
Caffeine downregulates antibody production in a mouse model
Pohanka, M. (2014) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2014.09.001 · Cited by 10 · see citing works
Coffee and stress management: How does coffee affect the stress response?
Raza, M. L., Haghipanah, M., & Moradikor, N. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.013 · Cited by 4 · see citing works
Environmental Toolkit to Promote Quality Sleep in Long-Term Care: A Quality Improvement Initiative
Frie, B., Graham, C., Hynes, A., Dusek, S., Heinen, L., Mehelich, M., & Campbell, K. A. (2021) · Journal of Long-Term Care · doi:10.31389/jltc.60 · Cited by 1 · see citing works
Cousins, J. C., Bell, I. R., & Bootzin, R. R. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00051-6
Intra-Individual Variability in Sleep Quality Among Coffee Consumers: A Cross-Sectional Study
Ramakrishn, S., Anbazhagan, D., Kumarasamy, V., & Kumarasamy, V. (2020) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2020.146.152
- Authors
- LLORET‐LINARES, C., LAFUENTE‐LAFUENTE, C., CHASSANY, O., GREEN, A., DELCEY, V., MOULY, S., & BERGMANN, J. F.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Venue
- Nutrition & Dietetics
- Publisher
- Wiley
- Published
- 2012-06-15
- Volume
- 69
- Issue
- 4
- Pages
- 250-255
- ISSN
- 1446-6368 (ISSN-L)
- 1747-0080
- OpenAlex
- W1502159292
- Cited by
- 14
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 2 · 2014: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition & Dietetics (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- coffee, caffeine, sleep quality, sleep disorders, sleep latency, nocturnal awakenings, caffeine sensitivity, decaffeinated coffee, healthy adults
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
