Automatic auditory discrimination is impaired in Parkinson’s disease
Abstract
Deviant tones embedded in a sequence of standard tones elicit an event-related potential (ERP) component called the mismatch negativity (MMN), which reflects automatic stimulus change detection in the human auditory system. To determine whether stimulus change detection is impaired in Parkinson's disease (PD), we recorded ERPs in 13 non-demented patients with PD and in 11 age-matched healthy control subjects both when tones were attended and when they were unattended. The difference area between deviant and standard ERPs was used to evaluate the MMN in the 'unattended' condition. The MMN was significantly smaller in patients with PD than in controls. In the attended condition, the amplitudes of both N1 and the N2 complex were smaller in the patient group than in controls. MMN attenuation suggests that PD patients have impaired automatic stimulus change detection compared with healthy controls. This might be caused by dopamine deficiency in PD.
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At the EEG, MMN duration, but not frequency, is negatively correlated with aging, resulting in impaired predictive errors.
“at the EEG, MMN duration, but not frequency, is nega tively correlated with aging, resulting in impaired predictive errors (Pekkonen et al., 1995).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Pekkonen et al., 1995
Individuals with Parkinson's disease showed impaired predictive coding compared to HC.
“individuals with Parkinson ' s disease showed impaired predictive coding compared to HC (Minks et al., 2014; Pek konen et al., 1995).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Pekkonen et al., 1995
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“Moreover, at the EEG, MMN duration, but not frequency, is negatively correlated with aging, resulting in impaired predictive errors (Pekkonen et al., 1995).”
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- Authors
- Pekkonen, E., Jousmäki, V., Reinikainen, K., & Partanen, J.
- Affiliations
- Kuopio University Hospital (FI)
- University of Helsinki (FI)
- Corresponding author
- Pekkonen, Eero
- Venue
- Electroencephalography and Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 95
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0013-4694 (ISSN-L)
- OpenAlex
- W1984731315
- Cited by
- 96
- References
- 24
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 15 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Electroencephalography and Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Keywords
- Parkinson's disease, mismatch negativity, auditory deviance detection, event-related potentials, auditory attention, dopamine deficiency, auditory processing deficits
- MeSH terms
- Acoustic Stimulation, Aged, Aged, 80 and over, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged, Parkinson Disease, Reaction Time, Multivariate Analysis
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