A theoretical and experimental study of high resolution EEG based on surface Laplacians and cortical imaging

Abstract

Two different methods to improve the spatial resolution of EEG are discussed: the surface Laplacian (e.g., current source density) and cortical imaging (e.g., spatial deconvolution). The former methods tend to be independent of head volume conductor model, whereas the latter methods are more model-dependent. Computer simulation of scalp potentials due to either a few isolated sources or 4200 distributed cortical sources and studies of actual EEG data both indicate that the two methods provide similar estimates of cortical potential distribution. Typical correlation coefficients between either spline-Laplacian or cortical image and simulated (calculated) cortical potential are in the 0.8-0.95 range, depending partly on CSF thickness. By contrast, correlation coefficients between simulated scalp and cortical potential are in the 0.4-0.5 range, suggesting that high resolution methods provide much better estimates of cortical potential than is obtained with conventional EEG. The two methods are also applied to steady-state visually evoked potentials and spontaneous EEG. Correlation coefficients obtained from real EEG data are in the same general ranges as correlations obtained from simulations. The new high resolution methods can provide a dramatic increase in the information content of EEG and appear to have widespread application in both clinical and cognitive studies.