Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters
Abstract
The effects of 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), buspirone and ipsapirone on wheel-running activity in hamsters were investigated in comparison with those of GABAA receptor agonist muscimol and benzodiazepine triazolam. Intraperitoneal administration of 8-OH-DPAT, buspirone, ipsapirone, muscimol and triazolam at circadian time (CT) 8 (CT 12; onset of activity) induced a significant phase advance of wheel-running activity under constant light conditions. However, administration of these drugs at other CT points did not induce phase changes. The administration of trifluoromethylphenylpiperazine (TFMPP), a 5-HT1B receptor agonist, at CT8 produced a small phase advance. The phase advance induced by 8-OH-DPAT was blocked by pretreatment with (-)-pindolol, a 5-HT1A receptor antagonist. In addition, 8-OH-DPAT, buspirone and SM3997 accelerated the rate of re-entrainment to an 8-h phase advance in the light-dark cycle. These observations suggest that 5-HT1A receptors in the brain participate in the regulation of the circadian rhythm of wheel-running activity in hamsters.
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In adult rodents, activation of serotonin receptors, either the 5-HT1A, 5-HT2, or 5-HT7 receptor subtypes, resets the phase of the suprachiasmatic nucleus circadian pacemaker.
“In adult rodents, activation of serotonin receptors, either the 5-HT1A, 5-HT2, or 5-HT7 receptor subtypes, resets the phase of the SCN circadian pacemaker (Tominaga et al., 1992; Gannon and Millan 2006; Ehlen et al., 2001; Duncan et al., 2004)”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Tominaga et al., 1992
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- Authors
- Tominaga, K., Shibata, S., Ueki, S., & Watanabe, S.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Tominaga, Keiko
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1992-04
- Volume
- 214
- Issue
- 1
- Pages
- 79-84
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1980396625
- Cited by
- 171
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT1A receptor agonist, circadian rhythm, wheel running, 8-OH-DPAT, buspirone, ipsapirone, muscimol, triazolam, phase advance, re-entrainment, light-dark cycle, hamster, serotonin receptors, pindolol
- MeSH terms
- Animals, Buspirone, Circadian Rhythm, Cricetinae, Male, Melatonin, Mesocricetus, Motor Activity, Pindolol, Piperazines, Receptors, GABA-A, Receptors, Serotonin, Tetrahydronaphthalenes, 8-Hydroxy-2-(di-n-propylamino)tetralin
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