Cited by 171Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters

Tominaga, Keiko, Shibata, Shigenobu, Ueki, Showa, Watanabe, Shigenori·1992·European Journal of Pharmacology

Abstract

The effects of 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), buspirone and ipsapirone on wheel-running activity in hamsters were investigated in comparison with those of GABAA receptor agonist muscimol and benzodiazepine triazolam. Intraperitoneal administration of 8-OH-DPAT, buspirone, ipsapirone, muscimol and triazolam at circadian time (CT) 8 (CT 12; onset of activity) induced a significant phase advance of wheel-running activity under constant light conditions. However, administration of these drugs at other CT points did not induce phase changes. The administration of trifluoromethylphenylpiperazine (TFMPP), a 5-HT1B receptor agonist, at CT8 produced a small phase advance. The phase advance induced by 8-OH-DPAT was blocked by pretreatment with (-)-pindolol, a 5-HT1A receptor antagonist. In addition, 8-OH-DPAT, buspirone and SM3997 accelerated the rate of re-entrainment to an 8-h phase advance in the light-dark cycle. These observations suggest that 5-HT1A receptors in the brain participate in the regulation of the circadian rhythm of wheel-running activity in hamsters.

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Crossref · 10.1016/0014-2999(92)90099-p

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40 of 40 references verified0 citation errors · 0 not checkable

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  • In adult rodents, activation of serotonin receptors, either the 5-HT1A, 5-HT2, or 5-HT7 receptor subtypes, resets the phase of the suprachiasmatic nucleus circadian pacemaker.

    “In adult rodents, activation of serotonin receptors, either the 5-HT1A, 5-HT2, or 5-HT7 receptor subtypes, resets the phase of the SCN circadian pacemaker (Tominaga et al., 1992; Gannon and Millan 2006; Ehlen et al., 2001; Duncan et al., 2004)”

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Authors
Tominaga, K., Shibata, S., Ueki, S., & Watanabe, S.
Affiliations
Kyushu University (JP)
Corresponding author
Tominaga, Keiko
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1992-04
Volume
214
Issue
1
Pages
79-84
ISSN
0014-2999 (ISSN-L)
OpenAlex
W1980396625
Cited by
171
References
40
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
9.36
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
5-HT1A receptor agonist, circadian rhythm, wheel running, 8-OH-DPAT, buspirone, ipsapirone, muscimol, triazolam, phase advance, re-entrainment, light-dark cycle, hamster, serotonin receptors, pindolol
MeSH terms
Animals, Buspirone, Circadian Rhythm, Cricetinae, Male, Melatonin, Mesocricetus, Motor Activity, Pindolol, Piperazines, Receptors, GABA-A, Receptors, Serotonin, Tetrahydronaphthalenes, 8-Hydroxy-2-(di-n-propylamino)tetralin

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