The role of the cingulum bundle in self-mutilation following peripheral neurectomy in the rat
Abstract
Peripheral neurectomy in rats is followed by self-mutilation of the denervated zone (autotomy), which is assumed to represent an index of pain or dysesthesia associated with deafferentation. This study examines the role of the cingulum bundle in mediating autotomy behavior. Rats were given bilateral injections of 1 microliter of 0.5% bupivicaine (a local anesthetic) or saline into the cingulum bundle immediately prior to, and on Days 1, 7, 14, and 21 after, sectioning the sciatic and saphenous nerves. Bupivicaine injections into the cingulum produced a significant delay in the onset of self-mutilation and reduced the overall degree of autotomy. Furthermore, the delayed onset of autotomy exceeded the duration of the anesthetic block produced by bupivicaine.
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Cingulum bundle anaesthesia delays the onset of self-mutilation following peripheral neurectomy.
“Related studies described how cingulum bundle anaesthesia delays the onset of self-mutilation following peripheral neurectomy (Vaccarino and Melzack, 1991; see also Magnusson and Vaccarino, 1996).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Vaccarino and Melzack, 1991
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Phantom limbs and the concept of a neuromatrix
Melzack, R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90179-e · Cited by 808 · see citing works
Self-citationAnalgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat
Vaccarino, A. L., & Melzack, R. (1989) · Pain · doi:10.1016/0304-3959(89)90008-0 · Cited by 104 · see citing works
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
“Related studies described how cingulum bundle anaesthesia delays the onset of self-mutilation following peripheral neurectomy (Vaccarino and Melzack, 1991; see also Magnusson and Vaccarino, 1996).”
- Authors
- Vaccarino, A. L., & Melzack, R.
- Affiliations
- McGill University (CA)
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 111
- Issue
- 1
- Pages
- 131-134
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1996449849
- Cited by
- 22
- References
- 2
- Citations by year
- 2021: 1 · 2018: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- cingulum, self-mutilation, autotomy, peripheral neurectomy, deafferentation, bupivacaine, sciatic nerve, saphenous nerve, pain, dysesthesia
- MeSH terms
- Afferent Pathways, Anesthetics, Animals, Denervation, Limbic System, Male, Peripheral Nerves, Rats, Inbred Strains, Self Mutilation, Rats
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