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Cited by 104Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

Analgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat

Vaccarino, Anthony L., Melzack, Ronald·1989·Pain
DOI 10.1016/0304-3959(89)90008-0
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Abstract

The role of cingulum in the perception of tonic and phasic pain was examined by injecting lidocaine, a local anesthetic, into the anterior cingulum bundle of the rat. A cannula was stereotaxically implanted into the anterior cingulum on one side in anesthetized rats. Seven to 10 days after surgery, the rats were infused with 1 microliter of 2% lidocaine in saline or saline alone into the anterior cingulum bundle immediately prior to testing for analgesia in the formalin or foot-flick test. Injection of lidocaine into the anterior cingulum bundle produced a significant reduction in formalin pain scores, but had no effect on foot-flick latencies. The analgesia in the formalin test persisted for the entire 40 min observation period. No analgesia in the formalin test was observed in rats that received injections of saline into the cingulum, lidocaine into the cingulum 90 min prior to testing or lidocaine into the cingulate cortex. These data suggest that the cingulum is involved in the perception of tonic pain but not phasic pain, and support previous studies which indicate that different neural mechanisms underlie different types of pain. Furthermore, these findings suggest that the cingulum is involved in the affective component of pain and that interruption of cingulum activity with lidocaine can produce analgesia.

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Crossref · 10.1016/0304-3959(89)90008-0

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54 of 54 references verified0 citation errors · 0 not checkable

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  • Blockade of the rat cingulum bundle can cause analgesia.

    “Initial research showed that blockade of the rat cingulum bundle can cause analgesia (Vaccarino and Melzack, 1989; 1992)”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Vaccarino and Melzack, 1989

  • The analgesic effect of rat cingulum bundle blockade is not due to adjacent cortical inactivation.

    “an effect not due to adjacent cortical inactivation (Vaccarino and Melzack, 1989)”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Vaccarino and Melzack, 1989

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Authors
Vaccarino, A. L., & Melzack, R.
Affiliations
McGill University (CA)
Corresponding author
Vaccarino, Anthony L.
ORCID
Vaccarino, Anthony L.
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1989-11
Volume
39
Issue
2
Pages
213-219
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/0304-3959(89)90008-0
OpenAlex
W1976377049
Cited by
104
References
55
Citations by year
2024: 1 · 2021: 3 · 2020: 1 · 2018: 5 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords
cingulate cortex, lidocaine, analgesia, tonic pain, phasic pain, formalin test, affective component of pain, pain perception, local anesthetic injection
MeSH terms
Analgesia, Animals, Gyrus Cinguli, Lidocaine, Male, Pain, Rats

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