Caenorhabditis elegans and Ascaris suum: inhibition of isocitrate lyase by itaconate
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Itaconate exhibits an antibiotic function via inhibition of isocitrate lyase, a key enzyme of the glyoxylate shunt needed by many bacteria to survive during infection.
“Itaconate exhibits an antibiotic function (20) via inhibition of isocitrate lyase, a key enzyme of the glyoxylate shunt needed by many bacteria to survive during infection (21)(22)(23).”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [21]
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Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
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“Itaconate is a potent suppressor of isocitrate lyase, the initiating enzyme of the glyoxlyate cycle used by bacteria when subjected to restricted nutrient conditions [122].”
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“In this capacity itaconate has been used for the study of anaplerotic sequences in a number of bacteria [7^10], some fungi [11], plants [12], and nematodes [13].”
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“ITA has direct antibacterial effects on other bacterial species, at least in part by inhibiting bacterial metabolic enzymes such as isocitrate lysase, which is part of the glyoxylate shunt pathway, propionyl-CoA carboxylase in the citramalate cycle, as well as methylisocitrate lyase in the 2-methylcitrate cycle (59, 6…”
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Szeligowski, R. V., Miros, F. N., Saez, A., DeCiucis, M., Wagner, G. P., & Shen, H. (2025) · eLife · doi:10.7554/elife.108012.1
- Authors
- Patel, T. R., & McFadden, B. A.
- Affiliations
- Washington State University (US)
- Venue
- Experimental Parasitology
- Publisher
- Elsevier BV
- Published
- 1978-04
- Volume
- 44
- Issue
- 2
- Pages
- 262-268
- ISSN
- 0014-4894 (ISSN-L)
- OpenAlex
- W2089668068
- Cited by
- 46
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 1
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- isocitrate lyase, itaconate, enzyme inhibition, Caenorhabditis elegans, Ascaris suum, non-competitive inhibition, enzyme purification, axenic culture, monoxenic culture, larval reproduction, TCA cycle
- MeSH terms
- Animals, Ascaris, Isocitrate Lyase, Oxo-Acid-Lyases, Nematoda, Succinates
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