Mechanism of action of isocitrate lyase from Pseudomonas indigofera
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of action of isocitrate lyase from Pseudomonas indigoferaBruce A. McFadden, Judith O. Williams, and Thomas E. RocheCite this: Biochemistry 1971, 10, 8, 1384–1390Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/bi00784a017https://doi.org/10.1021/bi00784a017research-articleACS PublicationsRequest reuse permissionsArticle Views500Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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4-OI alkylates KEAP1 on several cysteine residues, including C151.
“4-OI was shown to alkylate KEAP1 on several cysteine residues, namely cysteine 151 (C151), a principal redox sensing cysteine important for activation of Nrf259,66.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [66]
Itaconate exhibits an antibiotic function via inhibition of isocitrate lyase, a key enzyme of the glyoxylate shunt needed by many bacteria to survive during infection.
“Itaconate exhibits an antibiotic function (20) via inhibition of isocitrate lyase, a key enzyme of the glyoxylate shunt needed by many bacteria to survive during infection (21)(22)(23).”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [22]
Itaconate acts as a competitive SDH inhibitor in immune cells.
“our data suggest that itaconate acts as a competitive SDH inhibitor in immune cells”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [22]
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Isocitrate lyase from Pseudomonas indigofera
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Self-citationThe Kinetics of Adenylosuccinate Lyase
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Self-citationIsocitrate Lyase. Kinetics and Substrate-Tritium Exchange Reactions*
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Stereochemical Course of the Isocitrate Lyase Reaction
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Isocitrate lyase: Determination of Km values and inhibition by phosphoenol-pyruvate
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Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A. S., Sapcariu, S. C., Sousa, C., Koseki, H., Cabrales, P., Murphy, A. N., Hiller, K., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685792 · Cited by 526 · see citing works
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works
Itaconic acid is a mammalian metabolite induced during macrophage activation
Strelko, C. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., & Roberts, M. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2070889 · Cited by 391 · see citing works
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“It was first described in 1971 that itaconate effectively inhibits lyase (ICL) from the Gram-negative bacterium Vogesella indigofera (Williams et al., 1971).”
BackgroundCaenorhabditis elegans and Ascaris suum: inhibition of isocitrate lyase by itaconate
Patel, T. R., & McFadden, B. A. (1978) · Experimental Parasitology · doi:10.1016/0014-4894(78)90107-8 · Cited by 46 · see citing works
Self-citation
- Authors
- McFadden, B. A., Williams, J. O., & Roche, T. E.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1971-04-01
- Volume
- 10
- Issue
- 8
- Pages
- 1384-1390
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2006554051
- Cited by
- 99
- References
- 15
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- isocitrate lyase, enzyme mechanism, TCA cycle, enzyme kinetics, reaction mechanism
- MeSH terms
- Binding Sites, Chemistry, Glyoxylates, Hydrogen-Ion Concentration, Kinetics, Lyases, Maleates, Protein Binding, Pseudomonas, Pyruvates, Succinates, Chemical Phenomena
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