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Cited by 22Parasitic Diseases Research and TreatmentParasites and Host InteractionsNitric Oxide and Endothelin Effects

Dirofilaria immitis: Alteration of endothelium-dependent relaxation in the in vivo canine femoral artery

Kaiser, Lana, Spickard, Richard C., Sparks, Harvey V., Williams, Jeffrey F.·1989·Experimental Parasitology
DOI 10.1016/0014-4894(89)90165-3
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Abstract

Pathogenic mechanisms in filarial diseases are complex and poorly understood. While examining endothelium-dependent vasodilatory responses in the in vivo canine femoral artery, we noticed that dogs with Dirofilaria immitis infection had altered vascular responsiveness. The results reported here extend our original observations on vascular reactivity in dogs with D. immitis infection (L. Kaiser, J. F. Williams, E. A. Meade, and H. V. Sparks, 1987, American Journal of Physiology 253, H1325-H1329). In noninfected dogs, acetylcholine binds to the luminal endothelial cell muscarinic receptor. This results in release of a nonprostaglandin endothelium-derived relaxing factor. The relaxing factor causes an increase in vascular smooth muscle guanylate cyclase and relaxation. However, in dogs with D. immitis infection the mechanism of relaxation to acetylcholine is different. At least two endothelium derived relaxing factors are involved: the major factor is a prostaglandin; the second factor works through vascular smooth muscle cGMP. These data suggest that adult D. immitis release pharmacologically active factors that can alter distal endothelial cell function. The notion that filarial products may alter the physiological function of endothelial cells should be considered in the pursuit of improved understanding of pathogenic mechanisms of filariasis.

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  • D. immitis secretes pharmacologically active factors that can alter endothelial cell function.

    “These results suggest that D. immitis secretes pharmacologically active factors that can alter endothelial cell function (193).”

    From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [193]

  • Altered dilation of major arteries could explain, at least in part, the inability of dogs infected with D. immitis to adapt to circulatory demands during physical exertion.

    “Those authors also suggested that the derived altered dilation of major arteries could explain, at least in part, the inability of dogs infected with D. immitis to adapt to circulatory demands during physical exertion (193).”

    From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [193]

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Authors
Kaiser, L., Spickard, R. C., Sparks, H. V., & Williams, J. F.
Affiliations
Michigan State University (US)
ORCID
Williams, Jeffrey F.
Venue
Experimental Parasitology
Publisher
Elsevier BV
Published
1989-07
Volume
69
Issue
1
Pages
9-15
ISSN
0014-4894 (ISSN-L)
DOI
10.1016/0014-4894(89)90165-3
OpenAlex
W2010258156
Cited by
22
References
22
Citations by year
2025: 1 · 2022: 1 · 2019: 2 · 2017: 2 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Heart, Lung, and Blood Institute (HL-25779, HL-01842)
  • National Institute of Allergy and Infectious Diseases (AI16312)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
Dirofilaria immitis, canine heartworm disease, endothelium-dependent relaxation, femoral artery, acetylcholine, muscarinic receptors, endothelium-derived relaxing factor, prostaglandins, cyclic GMP, vascular smooth muscle
MeSH terms
Acetylcholine, Animals, Dirofilaria immitis, Dirofilariasis, Dogs, Endothelium, Vascular, Femoral Artery, Nitroglycerin, Methylene Blue, Muscle Relaxation, Muscle, Smooth, Vascular, Norepinephrine, Epoprostenol, Vasoconstriction, Vasodilation, Lipoxygenase Inhibitors

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