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Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca‐independent activation for shape‐change and secretion
Open accessAbstract
Cytoplasmic free [Ca 2+], [Ca 2+]i, was measured in human platelets using the intracellularly‐trapped, fluorescent indicator quin2. Basal [Ca 2+]i with the Ca 2+‐ionophore ionomycin revealed apparent thresholds for shape‐change, 5‐HT release and aggregation of approx. 0.5μM, 0.8μM and 2 μM. Thrombin raised [Ca 2+]i to 3 μM fast enough for the Ca 2+ to have triggered the cell activation. However, thrombin released more 5‐HT than ionomycin could, and in Ca 2+‐free medium thrombin evoked shape‐change and secretion even when [Ca 2+]i remained near basal levels throughout, suggesting the existence of alternative triggers for shape‐change and secretory exocytosis.
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Citations
Cited by
Activation of Platelet Function Through G Protein–Coupled Receptors
Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725
Rink, T. J., Sanchez, A., & Hallam, T. J. (1983) · Nature · doi:10.1038/305317a0 · Cited by 586
Self-citationSteenbergen, C., Murphy, E., Levy, L., & London, R. E. (1987) · Circulation Research · doi:10.1161/01.res.60.5.700 · Cited by 499
Mammalian non-pancreatic phospholipases A2
Kudo, I., Murakami, M., Hara, S., & Inoue, K. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90003-r · Cited by 351
Metadata
- Authors
- Rink, T. J., Smith, S. W., & Tsien, R. Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1982-11
- Volume
- 148
- Issue
- 1
- Pages
- 21-26
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2065993385
- Cited by
- 534
- References
- 0
- FWCI
- 36.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca‐independent activation for shape‐change and secretion. https://app.cochat.ai/papers/10.1016/0014-5793(82)81234-9
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- Rink, T. J., Smith, S. W., & Tsien, R. Y. (1982). Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca‐independent activation for shape‐change and secretion. FEBS Letters. https://doi.org/10.1016/0014-5793(82)81234-9
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