Cited by 312Iron Metabolism and DisordersMetal-Catalyzed Oxygenation MechanismsHemoglobin structure and function

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Identification of the ferroxidase centre in ferritin

Lawson, David M., Treffry, Amyra, Artymiuk, Peter J., Harrison, Pauline M., Yewdall, Stephen J., Luzzago, Alessandra, Cesareni, Gianne, Levi, Sonia, Arosio, Paolo·1989·FEBS Letters

DOI 10.1016/0014-5793(89)81040-3

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Abstract

Ferroxidase activity in human H‐chain ferritin has been studied with the aid of site‐directed mutagenesis. A site discovered by X‐ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H‐chains and is located within the four‐helix bundle of the chain fold.

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Background
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Authors: Lawson, D. M., Treffry, A., Artymiuk, P. J., Harrison, P. M., Yewdall, S. J., Luzzago, A., Cesareni, G., Levi, S., & Arosio, P.
Affiliations: University of Sheffield (GB)
European Molecular Biology Laboratory (DE)
University of Rome Tor Vergata (IT)
University of Milan (IT)
Corresponding author: Artymiuk, Peter J.
ORCID: Levi, Sonia
Arosio, Paolo
Venue: FEBS Letters
Publisher: Wiley
Published: 1989-08-28
Volume: 254
Issue: 1-2
Pages: 207-210
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(89)81040-3
OpenAlex: W1987119816
Cited by: 312
References: 13
Citations by year: 2026: 4 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 11 · 2012: 10
FWCI: 8.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4435 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: ferritin, iron oxidation, site-directed mutagenesis, four-helix bundle, protein structure, iron storage
MeSH terms: Animals, Binding Sites, Ferritins, Horses, Humans, Mutation, Oxidoreductases, Protein Conformation, Recombinant Proteins, X-Ray Diffraction, Rats

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Identification of the ferroxidase centre in ferritin

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