The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α2‐macroglobulin receptor
Open accessAbstract
The human placental receptor (α 2 MR) for α 2‐macroglobulin‐proteinase complexes contains 3 polypeptides of approx. 500 kDa, 85 kDa, and 40 kDa. N‐terminal sequence analysis of the 500 kDa and 85 kDa polypeptides, analysis of a random selection of peptides covering 536 residues from these polypeptides, and analysis of a 1772 bp cDNA encoding part of the 500 kDa polypeptide provide evidence that the 500 kDa and 85 kDa chains are the α‐ and β‐subunits, respectively, of a recently cloned hepatic membrane protein, termed the low density lipoprotein receptor related protein (LRP) (Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H. and Stanley, K.K. (1988) EMBO J. 7, 4119‐4127; Herz, J., Kowal, R.C., Goldstein, J.L. and Brown, M.S. (1990) EMBO J. 9, 1769‐1776). N‐terminal sequence analysis of the 40 kDa polypeptide shows that it is of distinct genetic origin. It is suggested that LRP is the functional receptor for α 2‐macroglobulin‐proteinase complexes (α 2 MR) and in addition may have as yet unsettled functions in lipoprotein metabolism.
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Cites
Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87014-4 · Cited by 445
Cited by
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
Hobbs, H. H., Brown, M. S., & Goldstein, J. L. (1992) · Human Mutation · doi:10.1002/humu.1380010602 · Cited by 921
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Lillis, A. P., Van Duyn, L. B., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 669
Herz, J., Clouthier, D. E., & Hammer, R. E. (1992) · Cell · doi:10.1016/0092-8674(92)90511-a · Cited by 497
Herz, J., Goldstein, J. L., Strickland, D. K., Ho, Y. K., & Brown, M. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54845-6 · Cited by 482
Metadata
- Authors
- Kristensen, T., Moestrup, S. K., Gliemann, J., Bendtsen, L., Sand, O., & Sottrup-Jensen, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-12-10
- Volume
- 276
- Issue
- 1-2
- Pages
- 151-155
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1991700287
- Cited by
- 322
- References
- 1
- FWCI
- 28.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kristensen, T., Moestrup, S. K., Gliemann, J., Bendtsen, L., Sand, O., & Sottrup-Jensen, L. (1990). Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α2‐macroglobulin receptor. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80530-v
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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