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LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

Herz, Joachim, Clouthier, David E., Hammer, Robert E.·1992·Cell
DOI 10.1016/0092-8674(92)90511-a
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Abstract

The low density lipoprotein receptor-related protein (LRP) is a large multifunctional clearance receptor that has been implicated in the hepatic uptake of chylomicron remnants and in the removal of protease-inhibitor complexes from the circulation and from the extracellular space. Disruption of the LRP gene in mice blocks development of LRP-/- embryos around the implantation stage. The expression pattern of LRP in the postimplantation stage embryo is identical to that of urokinase, a plasminogen activator that confers invasive properties to migrating cells. We demonstrate that LRP mediates uptake and degradation of urokinase-type plasminogen activator-plasminogen activator inhibitor 1 complexes and propose that the inability of the giant cells to remove the inactive protease complexes from their surfaces interferes with implantation of the embryo.

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Metadata

Authors
Herz, J., Clouthier, D. E., & Hammer, R. E.
Venue
Cell
Publisher
Elsevier BV
Published
1992-10
Volume
71
Issue
3
Pages
411-421
ISSN
0092-8674
DOI
10.1016/0092-8674(92)90511-a
Cited by
497
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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