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Cited by 482

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

Herz, J., Goldstein, J.L., Strickland, D.K., Ho, Y.K., Brown, M.S.·1991·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)54845-6
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Abstract

A 39-kDa protein of unknown function has previously been reported to copurify with the low density lipoprotein receptor-related protein (LRP)/alpha 2-macroglobulin receptor. In this study we demonstrate that a recombinant 39-kDa fusion protein can reversibly bind to the 515-kDa subunit of the LRP/alpha 2-macroglobulin receptor. This interaction inhibits the binding and uptake of the receptor's two known ligands: 1) beta-migrating very low density lipoproteins activated by enrichment with apoprotein E and 2) alpha 2-macroglobulin activated by incubation with plasma proteases or methylamine. A potential in vivo role of the 39-kDa protein is to modulate the uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in hepatic and extrahepatic tissues.

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Crossref · 10.1016/s0021-9258(18)54845-6

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1 of 1 references verified0 citation errors · 0 not checkable

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 27

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Metadata

Authors
Herz, J., Goldstein, J. L., Strickland, D. K., Ho, Y. K., & Brown, M. S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1991-11
Volume
266
Issue
31
Pages
21232-21238
ISSN
0021-9258
DOI
10.1016/s0021-9258(18)54845-6
Cited by
482
References
1
Language
en
Licence

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