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Cited by 472

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

Open access
Kawajiri, Kaname, Nakachi, Kei, Imai, Kazue, Yoshii, Akira, Shinoda, Nahomi, Watanabe, Junko·1990·FEBS Letters

Abstract

A good correlation was observed between enhanced lung cancer risk and restriction fragment length polymorphisms (RFLPs) of the P450IA1 gene with the restriction enzyme Msp I. Genotype frequencies of 0.49 for the predominant homozygote, 0.40 for the heterozygote, and 0.11 for the homozygous rare allele were observed in a healthy population. Among lung cancer patients, the frequency of homozygous rare allele of P450IA1 gene was found to be about 3‐fold higher than that among healthy population, and this difference was statistically significant. This is the first report to identify the genetically high risk individuals to lung cancer at the gene level.

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Metadata

Authors
Kawajiri, K., Nakachi, K., Imai, K., Yoshii, A., Shinoda, N., & Watanabe, J.
Venue
FEBS Letters
Publisher
Wiley
Published
1990-04-09
Volume
263
Issue
1
Pages
131-133
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W1974372375
Cited by
472
References
10
FWCI
17.85
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene. https://app.cochat.ai/papers/10.1016/0014-5793(90)80721-t
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Kawajiri, K., Nakachi, K., Imai, K., Yoshii, A., Shinoda, N., & Watanabe, J. (1990). Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80721-t

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