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Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo
Open accessAbstract
A series of dioleoyl N‐(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG‐PE) of different polymer chain length was used in this study. Both the activity of PEG‐PE in prolonging the circulation time of liposomes and the relative steric barrier activity of amphipathic polymer, measured by a liposome agglutination assay, were found to be directly proportional to the chain length of PEG‐PE (PEG5000‐PE > PEG2000‐PE > PEG750‐PE). However, PEG5000‐PE caused a reduced target binding of immunoliposomes in mice due to its overly strong steric barrier activity. The best PEG‐PE species supporting the target binding of immunoliposomes was PEG2000‐PE, the activity of which was compatible to that of ganglioside GM 1. However, GM 1 only showed a weak steric barrier activity, suggesting a different mechanism for this glycolipid.
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Cited by
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523
Nanoparticle PEGylation for Imaging and Therapy
Jokerst, J. V., Lobovkina, T., Zare, R. N., & Gambhir, S. S. (2011) · Nanomedicine · doi:10.2217/nnm.11.19 · Cited by 2,046
Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561
Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178
Metadata
- Authors
- Mori, A., Klibanov, A. L., Torchilin, V. P., & Huang, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1991-06-24
- Volume
- 284
- Issue
- 2
- Pages
- 263-266
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2005556449
- Cited by
- 369
- References
- 0
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. https://app.cochat.ai/papers/10.1016/0014-5793(91)80699-4
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- Mori, A., Klibanov, A. L., Torchilin, V. P., & Huang, L. (1991). Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Letters. https://doi.org/10.1016/0014-5793(91)80699-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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