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The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide
Abstract
We have cloned and sequenced a cDNA (RPR4) encoding a new member of the secretin/calcitonin/parathyroid hormone (PTH) receptor family. RPR4 was identified by PCR of rat pituitary cDNA, and a full‐length clone was isolated from a rat olfactory bulb cDNA library. When RPR4 was functionally expressed in COS 7 cells, cyclic adenosine monophosphate (cAMP) production was stimulated by vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptides (PACAP‐38 and PACAP‐27) and helodermin, with equal potency. Peptide histidine isoleucine (PHI) and rat growth hormone releasing hormone (rGHRH) also stimulated cAMP production at lower potency. This suggests that RPR4 encodes a novel VIP receptor which we have designated the VIP 2 receptor. In situ hybridisation showed that mRNA for this receptor was present mainly in the thalamus, hippocampus and in the suprachiasmatic nucleus.
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Cited by
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
Vaudry, D., Gonzalez, B. J., Basille, M., Yon, L., Fournier, A., & Vaudry, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01449-2 · Cited by 1,121
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Villalba, M., Bockaert, J., & Journot, L. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00083.1997 · Cited by 306
Akahoshi, M., Song, C. H., Piliponsky, A. M., Metz, M., Guzzetta, A., Åbrink, M., Schlenner, S. M., Feyerabend, T. B., Rodewald, H.-R., Pejler, G., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46139 · Cited by 135
Metadata
- Authors
- Lutz, E. M., Sheward, W. J., West, K. M., Morrow, J. A., Fink, G., & Harmar, A. J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1993-11-08
- Volume
- 334
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2024697593
- Cited by
- 497
- References
- 0
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lutz, E. M., Sheward, W. J., West, K. M., Morrow, J. A., Fink, G., & Harmar, A. J. (1993). The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide. FEBS Letters. https://doi.org/10.1016/0014-5793(93)81668-p
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