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hBD‐1: a novel β‐defensin from human plasma
Open accessAbstract
We report the isolation and characterization of a novel peptide with significant sequence homology to β‐defensins from human blood filtrate. The human β‐defensin‐1 (hBD‐1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD‐1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD‐1 shares the nine conserved amino acids characteristic for β‐defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD‐1 is present in nanomolar concentration in human plasma.
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Citations
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
Self-citationIsolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
Harder, J., Bartels, J., Christophers, E., & Schröder, J.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,311
Bals, R., Wang, X., Zasloff, M., & Wilson, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9541 · Cited by 746
Metadata
- Authors
- Bensch, K. W., Raida, M., Mägert, H.-J., Schulz-Knappe, P., & Forssmann, W.-G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-07-17
- Volume
- 368
- Issue
- 2
- Pages
- 331-335
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2040597252
- Cited by
- 545
- References
- 0
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bensch, K. W., Raida, M., Mägert, H.-J., Schulz-Knappe, P., & Forssmann, W.-G. (1995). hBD‐1: a novel β‐defensin from human plasma. FEBS Letters. https://doi.org/10.1016/0014-5793(95)00687-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
