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Neutrophils convert tyrosyl residues in albumin to chlorotyrosine
Open accessAbstract
Hypochlorous acid chlorinates tyrosyl residues in small peptides to produce chlorotyrosine. Detection of chlorotyrosine has the potential to unequivocally identify the contribution hypochlorous acid makes to inflammation. I have developed a selective and sensitive HPLC assay for measuring chlorotyrosine. When albumin was exposed to reagent hypochlorous acid, or that produced by myeloperoxidase and stimulated neutrophils, tyrosyl residues in the protein were converted to chlorotyrosine. About 2% of the hypochlorous acid generated by neutrophils was accounted for by the formation of chlorotyrosine. These results demonstrate that chlorotyrosine will be a useful marker for establishing a role for hypochlorous acid in host defence and inflammation.
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Citations
Cites
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Cited by
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Pattison, D. I., & Davies, M. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0155451 · Cited by 790
What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
Halliwell, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00469-9 · Cited by 472
Stable markers of oxidant damage to proteins and their application in the study of human disease
Davies, M. J., Fu, S., Wang, H., & Dean, R. T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00206-3 · Cited by 461
Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid
Eiserich, J. P., Cross, C. E., Jones, A. D., Halliwell, B., & van der Vliet, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19199 · Cited by 447
Metadata
- Authors
- Kettle, A. J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-01-22
- Volume
- 379
- Issue
- 1
- Pages
- 103-106
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2132416882
- Cited by
- 187
- References
- 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kettle, A. J. (1996). Neutrophils convert tyrosyl residues in albumin to chlorotyrosine. FEBS Letters. https://doi.org/10.1016/0014-5793(95)01494-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
