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A photo‐reactive derivative of ganglioside GM1 specifically cross‐links VIP21‐caveolin on the cell surface
Abstract
Previous studies have shown that sphingolipids may be enriched in caveolae, plasmalemmal invaginations implicated in endocytosis and signal transduction. We synthesised a radiolabeled derivative of ganglioside GM1 bearing a photo‐reactive cross‐linker at the end of its acyl chain. After insertion in the plasma membrane of cultured A431 or MDCK cells and photoactivation, the main protein cross‐linked by the GM1 derivative was VIP21‐caveolin, an essential structural component of caveolae. This result shows close proximity between GM1 molecules and VIP21‐caveolin in the caveolar membrane and strongly implicates sphingolipid segregation in the biogenesis of caveolae.
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Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
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Xavier, R., Brennan, T., Li, Q., McCormack, C., & Seed, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80577-4 · Cited by 690
Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo
Schubert, W., Frank, P. G., Razani, B., Park, D. S., Chow, C.-W., & Lisanti, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100613200 · Cited by 337
Galbiati, F., Volonté, D., Chu, J. B., Li, M., Fine, S. W., Fu, M., Bermudez, J., Pedemonte, M., Weidenheim, K. M., Pestell, R. G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160249097 · Cited by 155
Engelman, J. A., Zhang, X. L., Galbiati, F., & Lisanti, M. P. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00619-x · Cited by 145
Metadata
- Authors
- Fra, A. M., Masserini, M., Palestini, P., Sonnino, S., & Simons, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-11-13
- Volume
- 375
- Issue
- 1-2
- Pages
- 11-14
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2152333523
- Cited by
- 177
- References
- 0
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fra, A. M., Masserini, M., Palestini, P., Sonnino, S., & Simons, K. (1995). A photo‐reactive derivative of ganglioside GM1 specifically cross‐links VIP21‐caveolin on the cell surface. FEBS Letters. https://doi.org/10.1016/0014-5793(95)95228-o
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
